研究结论和讨论部分意义重大。该研究揭示了 FTD 患者不仅存在小脑病变，而且小脑 - 大脑的神经回路也受到严重影响。小脑与 FTD 相关的皮质区域之间的连接特别脆弱，这表明小脑功能障碍在 FTD 的运动和神经心理缺陷中起着重要作用。例如，研究中发现的脊髓小脑束病变和小脑萎缩，可能是患者步态障碍和平衡失调的原因之一。而且，在非 ALS 的 FTD ...

One possibility explored by Piguet et al. is that too many features were treated as 'necessary' in the published bvFTD criteria. The use of fewer features increased the percentage of individuals ...

But for people with behavioral variant frontotemporal dementia (bvFTD), this basic neural response gradually disappears, fundamentally changing how they relate to others’ emotions. Now ...