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综述:核糖体的 “反叛”:蛋白质工厂如何推动癌症进展
两篇发表于《癌细胞》(Cancer Cell)的研究揭示了蛋白质合成机制促进癌症进展的机制及潜在治疗干预手段。Kuzuoglu-Ozturk 等人发现 eIF4A 介导的致癌转录本翻译起始增强会推动癌症进展;Weller 等人则展示异常转运 RNA(tRNA)修饰如何破坏翻译保真度产生新抗原。值得关注!
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