When the mechanisms that replicate or repair mitochondrial DNA (mtDNA) fail, it can cause a wide range of syndromes for which there are few to zero existing treatment options. One of the causes of ...

Mitochondrial diseases, arising from mutations in mitochondrial DNA (mtDNA), are a diverse group of disorders that lead to severe conditions. Expression of mtDNA is a prerequisite for ATP production ...

结果发现运动抑制了 TWIK2 - mtDNA - NLRP3 炎性小体信号，改善肝脏胰岛素抵抗，为代谢疾病防治提供新靶点。 运动已被证实能有效改善糖尿病，但潜在机制仍不明确。近期研究表明，核苷酸结合寡聚化结构域样受体蛋白 3（NLRP3 ）炎性小体的过度激活会导致肝脏 ...

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, P. R. China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention ...

But according to a recent study published in the journal Environmental Research, exposure to green spaces may have a positive relationship with the Mitochondrial DNA copy number, or mtDNA-CN, in ...

Within the core program, TFE3 fusions directly regulate genes involved in ferroptosis resistance and oxidative phosphorylation metabolism (OxPhos). Consequently, human tRCC tumors display high OxPhos ...

为解决线粒体 DNA（mtDNA）变异作为可靠谱系标记的效能受其复杂动态影响的问题，研究人员开展了线粒体谱系追踪研究。通过模拟和实验，发现克隆扩增程度影响线粒体谱系追踪效能，还提出谱系信息评分（LIS）。这为线粒体谱系追踪应用提供了重要指导。

线粒体，被称为细胞的“能量工厂”，其内部的 DNA（mtDNA）掌控着能量代谢的关键基因。mtDNA 的突变会引发多种严重遗传病，例如 Leigh综合征、MELAS 综合征等。然而，传统的 CRISPR 基因编辑工具难以编辑线粒体 DNA，科学家们一直在寻找突破。 2025 年 3 月 25 日 ...

1 Graduate School, Harbin Sport University, Harbin, Heilongjiang, China 2 College of Human Sport Science, Harbin Sport University, Harbin, Heilongjiang, China Ferroptosis, a distinct form of ...

State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China ...