Phagocytosis is a fundamental mechanism used by the body to resist pathogens and restore physiological homeostasis. Herein, to identify small molecules with anti-inflammatory properties via ...

Actin is a globular protein that is a major constituent of the cellular cytoskeleton. Actin can exist in monomeric form as G-actin (globular actin) or can form filaments (F-actin, filamentous ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Stimulator of interferon genes (STING) is ...

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany Center for ...

RT-qPCR was performed according to standard protocols, with conditions of 95°C for 3 min, followed by 45 cycles of denaturation at 95°C for 5 s, annealing at 60°C, and extension for 34 s. Gene ...

She is passionate about making complex scientific concepts accessible to readers. View Full Profile. Learn about our Editorial Policies. Quantitative polymerase chain reaction (qPCR) is a molecular ...

were mixed with 5 μl of reaction mix [PyroTaq EvaGreen qPCR Mix Plus (ROX) (CMBTM) and both forwards and reverse primers at 0.5 mM] in 384-well plates. Wells containing 3 μl of water instead of cDNA ...

Actin filaments assemble inside the nucleus in response to multiple cellular perturbations, including heat shock, protein misfolding, integrin engagement, and serum stimulation. We find that DNA ...