REAL AD hints that blood markers can spot subtle cognitive decline. People who fluff a digital cognitive test have more ...

Immunoassay or Mass Spec? In secondary care, Lumipulse p-tau217 and MS p-tau217 or %p-tau217 are similarly accurate. In ...

Scientists see several important uses for staging. For example, it can steer people more precisely to appropriate treatments.

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

The National Alzheimer’s Coordinating Center unites the collections of the neuropathology cores at 27 NIA-funded AD Research Centers into a single database. It contains records on 13,000 brains, 3,000 ...

We are pleased to present exclusive short films from “The Alzheimer’s Project,” sponsored by HBO Documentary Films and the National Institute on Aging of the National Institutes of Health, with ...

PSEN1 encodes presenilin-1, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. More than 300 mutations in PSEN1 have been reported and mutations in PSEN1 are the most ...

See α-Synuclein. Candidate tracer SY08 detects α-synuclein deposits in the brainstem (right) and parietal cortex (left) of ...

A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...

Dozens of rodents have been generated that model various aspects of ALS, like motor impairment or degeneration of motor neurons. No model recapitulates the human disease perfectly. By organizing ...