Dopamine receptor D 2, also known as D 2 R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard 's lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups, including those of Solomon H. Snyder and Philip Seeman used a radiolabeled antipsychotic drug to ...

D2-receptors inhibit both the P/Q- and N-type calcium channels (Cardozo and Bean, 1995) that are responsible for the calcium entry triggering dopamine release (Phillips and Stamford, 2000).

多巴胺受體D 2 （ Dopamine receptor D 2 ，簡稱D2R），為轉譯自 DRD2 基因的一種多巴胺受體蛋白。D2R最早於1975年為 Philip Seeman （ 英语 ： Philip Seeman ） 所發現，並將其命名為「抗精神疾患性多巴胺受體」（antipsychotic dopamine receptor） [8] 。D2R為所有抗精神病药物的 …

2023年6月22日 · The D1 receptor is the most abundant out of the five in the central nervous system, followed by D2, then D3, and D5, and the least abundant is D4. D1 receptors help regulate the development of neurons when the dopamine hormone binds to them.

多巴胺受体家族属于G蛋白（由Gα和Gβγ三个亚基组成）偶联 受体超家族 （G-Protein-Coupled Receptor，GPCR），包含五个成员：DRD1、DRD2、DRD3、DRD4和DRD5。 其中，DRD1和DRD5属于D1类受体，与激活型G蛋白Gs偶联，刺激 第二信使 cAMP的产生；而DRD2、DRD3和DRD4属于D2类受体，与 ...

多巴胺受體D 2 （ Dopamine receptor D 2 ，簡稱D2R），為轉譯自 DRD2 基因的一種多巴胺受體蛋白。 D2R最早於1975年為 Philip Seeman （ 英語 ： Philip Seeman ） 所發現，並將其命名為「抗精神疾患性多巴胺受體」（ antipsychotic dopamine receptor ） [ 8 ] 。

The D 2 receptor is the prototypical and most abundant member of the D 2-like dopamine receptor subfamily, which consists of the D 2, D 3, and D 4 receptors. D 2 receptors are found both post- and pre-synaptically in the nervous system and couple to heterotrimeric Gi/o proteins to inhibit adenylate cyclase and/or calcium channels or modulate ...

Dopamine controls various physiological functions in the brain and periphery by acting on its receptors D1, D2, D3, D4, and D5. Dopamine receptors are G protein–coupled receptors involved in the regulation of motor activity and several neurological ...

The D 2-like receptors are coupled to the Gαi/o-protein to inhibit the activity of AC and thus reduce intracellular cAMP production (Beaulieu, et al., 2015). The D 2-like receptors are present on DA and non-DA neurons and control neuron excitability and the release of neurotransmitters including DA, glutamate, GABA and acetylcholine.

2000年11月9日 · By a mechanism of alternative splicing, the D2 receptor gene encodes two molecularly distinct isoforms9, D2S and D2L, previously thought to have the same function.