2006年7月25日 · In most cases this will consist of either unfractionated heparin or low molecular weight heparin (LMWH). Unfraction-ated heparin at a dose of 5000 U subcutaneous twice or three times daily is the preferred anticoagulant in North America, while LMWH at prophylactic doses is used most frequently in Europe.

2011年1月24日 · In the present manuscript we often refer to heparin, not discriminating between unfractionated heparin and low molecular weight heparin (LMWH). Clinicians should, however, be aware of their differences [2]. LMWHs have a lower antithrombin (AT) dependency, cause less tissue plasminogen activator inhibitor depletion, exhibit less binding to proteins and cells, …

2015年12月1日 · The recent guideline from the Kidney Disease Improving Global Outcomes (KDIGO) working group recommended citrate as the first-line anticoagulant for continuous renal replacement therapy (CRRT) [2]. For patients with contraindications to citrate, either unfractionated or low molecular weight heparin was recommended.

2010年3月18日 · Introduction Intensive care unit (ICU) patients are predisposed to thromboembolism. Routine prophylactic anticoagulation is widely recommended. Low-molecular-weight heparins, such as enoxaparin, are increasingly used because of predictable pharmacokinetics. This study aims to determine the subcutaneous (SC) dose of enoxaparin …

2020年6月10日 · This letter is to alert physicians as to the high incidence of ARC in these patients and provide warning regarding the fact that regular doses of low molecular weight heparin might not be protective enough for DVT and PE in this type of COVID-19 patient.

2014年10月16日 · Low-molecular-weight heparin can also effectively reduce the incidence of DVT. Moreover, studies have revealed different anticoagulant mechanisms for thrombin inhibition between unfractionated heparin and low-molecular-weight heparin [38].We attempted to perform a subgroup analysis on the two types of heparin.

2010年4月21日 · Venous thromboembolism is a relatively frequently occurring complication in critically ill patients admitted to the ICU despite prophylactic treatment with subcutaneous low molecular weight heparin. Several studies show that critically ill patients have significantly lower plasma anti-factor-Xa activity levels compared to control patients after administration of …

2014年4月25日 · Introduction Heparin is safe and prevents venous thromboembolism in critical illness. We aimed to determine the guideline concordance for thromboprophylaxis in critically ill patients and its predictors, and to analyze factors associated with the use of low molecular weight heparin (LMWH), as it may be associated with a lower risk of pulmonary embolism and …

2005年8月9日 · Introduction Deep venous thrombosis with subsequent pulmonary embolism or post-thrombotic syndrome is a feared complication in the intensive care unit. Therefore, routine prophylactic anticoagulation is widely recommended. Aside from unfractionated heparin, low molecular weight heparins, such as certoparin, have become increasingly used for …

2011年3月22日 · Heparin-induced thrombocytopenia (HIT) is one of the most serious adverse events associated with this drug. HIT is an immune-mediated, prothrombotic complication that occurs with unfractionated heparin (UFH) and to a lesser extent with …