2023年8月30日 · Preliminary research suggests L-arginine and L-citrulline are linked to lower blood pressure, but more research is needed to find a safe and effective dose.

Citrullination or deimination is the conversion of the amino acid arginine in a protein into the amino acid citrulline. Citrulline is not one of the 20 standard amino acids encoded by DNA in the genetic code. Instead, it is the result of a post-translational modification.

Arginine/citrulline has immense therapeutic potential in some life-threatening diseases of children including cardiovascular function in hypertension and pulmonary hypertension.

2003年7月15日 · In this study, we show that the conversion of arginine to citrulline, a process which replaces the charged imino side-chain group with an uncharged carbonyl, dramatically increases the affinity of the vimentin peptide for DRB1*0401.

This review aimed to investigate whether oral administration of the amino acids l-arginine (Arg) and l-citrulline (Cit), which are potential substrates for eNOS, could effectively reduce BP by increasing NO production. Both Arg and Cit are effective at increasing plasma Arg. Cit is approximately twice as potent, which is most likely due to a ...

When you take L-arginine and L-citrulline together, they create a dynamic duo that enhances nitric oxide production far more effectively than either alone. This synergistic effect can lead to better blood flow, reduced blood pressure, and improved athletic performance.

The rate of conversion of citrulline to arginine (de novo arginine synthesis) increased linearly with increasing concentration of citrulline supplementation (P < 0.001), whereas it remained unaffected by arginine supplementation (P = 0.97) .

2018年2月7日 · Nitric oxide (NO) protects against the progression of atherosclerosis and is synthesized by nitric oxide synthase (NOS), which converts L-arginine (L-Arg) into L-citrulline (L-Cit). Our previous study revealed that chronic administration of a combination of L-Cit and L- Arg has a better therapeutic effect on high cholesterol-induced ...

2014年11月7日 · Oral l -citrulline plus l -arginine rapidly raises plasma l -arginine levels. Combined administration causes a significantly greater increase in plasma NO x and cGMP. Blood flow is also significantly increased by l -citrulline plus l -arginine. This study proposes a novel strategy to rapidly potentiate NO–cGMP dependent reactions.

2003年7月15日 · In this study, we demonstrate that the conversion of arginine to citrulline at the peptide side-chain position interacting with the shared epitope significantly increases peptide-MHC affinity and leads to the activation CD4(+) T cells in DR4-IE tg mice.