2021年1月21日 · We aimed to determine the significance of cytoplasmic antinuclear antibody (ANA) patterns using computer-aided immunofluorescence microscopy in patients with autoimmune liver diseases (AILD). ANA staining pattern was identified by treating cultured human epithelial type 2 (HEp-2) cells with the sera of the patients.

2019年2月7日 · Although the test name refers to only anti-nuclear antibody, there are often cytoplasmic staining patterns overserved in this assay. Cytoplasmic patterns result from antibodies against cytoplasmic components, like Jo-1 or Ribosomal P, and have clinical association with various systemic autoimmune disease, like polymyositis, systemic lupus ...

Positive test results for ANCAs reveal one of two basic patterns of staining: cytoplasmic (c-ANCA) or perinuclear (p-ANCA). The c-ANCA indicates the presence of antibodies directed against proteinase 3.

2019年11月30日 · Titers are often reported and followed over time to analyze the course of a possible illness. ANA is a screening test, and somewhat controversial due to frequent false positives. Still have questions? Get the best care from a doctor who knows you. Not much info added: Diffuse and speckled antinuclear antibodies are the least specific.

The cytoplasmic staining shown by anti-Jo-1 (histidyl tRNA synthetase) antibodies in PM/DM or antimitochondrial antibodies in primary biliary cirrhosis (PBC) is often either not reported or incorrectly interpreted.

2024年2月21日 · Cytoplasmic pattern: Variety of staining patterns. May be associated with hepatitis, hepatitis C, lupus, myositis, or sometimes mean nothing at all; The Dense Fine Speckled Pattern. One pattern that deserves special attention is …

2021年1月7日 · We aimed to determine the significance of cytoplasmic antinuclear antibody (ANA) patterns using computer-aided immunofluorescence microscopy in patients with autoimmune liver diseases (AILD). ANA staining pattern was identified by treating cultured human epithelial type 2 (HEp-2) cells with the sera of the patients.

Antinuclear antibody (ANA) testing is useful as an initial screen for autoimmune diseases such as Sjögren syndrome, systemic lupus erythematosus, and scleroderma. ANA test results provide patterns that may be suggestive of a specific autoimmune disease or diseases. Refer to ARUP Laboratories’ test offerings below.

2024年8月11日 · The indirect immunofluorescence identifies ANCA by its staining patterns inside the cytoplasm of neutrophils. In this technique, neutrophils are fixed via ethanol onto a slide; the blood sample is then mixed on the slide with the neutrophils; if present, ANCA in the sample attaches to neutrophils on the slide.

2024年10月21日 · Cytoplasmic staining patterns on ANA-Hep-2 are gaining recognition but with scanty information about their clinical and diagnostic role. The aim is to assess the frequency of cytoplasmic ANA patterns in autoimmune diseases, and to evaluate their possible associations with clinical diagnoses and autoantibodies.