2021年5月13日 · The use of chiral BOX-based ligand enables the direct access of chiral secondary alkyl-substituted amine and alcohol derivatives in good yields with excellent levels of enantioselectivity ...

2021年10月22日 · By using iridium catalyst C3b with a chiral spiro phosphine-oxazoline ligand (SIPHOX), a wide variety of chiral amines P29 were attained in excellent yields and enantioselectivities via direct catalytic AH of 2-pyridyl cyclic imines S29 .

The resultant biocatalysts showed broad applicability toward the synthesis of chiral amines that previously were accessible only via resolution. This work underscores the maturation of biocatalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.

2022年1月12日 · During the past decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetric hydrogenation (AH). The present review covers the use of AH in the synthesis of chiral amines bearing a stereogenic center either in the α, β, or γ position with respect to ...

2023年4月10日 · Recent advances in enzymatic cascade engineering have attracted attention due to efficient and environmentally friendly routes to synthesize chiral amines. Enzymatic cascades can reduce the traditional multistep synthesis and have enabled the generation of chiral products from cheap starting materials.

2022年6月16日 · As a new biocatalyst, amine dehydrogenases (AmDHs) catalyze the asymmetric formation of chiral amines by ketones. The purpose of this review is to provide a general overview of reported types of natural and engineered AmDHs, their catalytic mechanisms, and the design and application of bioreactors.

Chiral amines are key structural motifs present in a wide variety of natural products, drugs, and other biologically active compounds. During the past decade, significant advances have been made with respect to the enantioselective synthesis of chiral amines, many of them based on catalytic asymmetric hydrogenation (AH).

2023年3月20日 · Here we report the use of chiral tridentate anionic ligands to enable the copper-catalysed chemoselective and enantioconvergent N -alkylation of aliphatic amines with α-carbonyl alkyl chlorides.

2023年3月16日 · Chiral aliphatic amines are privileged functionalities in pharmaceutical molecules and play an essential role as ligands and catalysts in organic synthesis. It is therefore important to develop...

2021年12月3日 · Here we developed a proof-of-concept bi-enzymatic cascade, consisting of an ene reductase and amine dehydrogenase (AmDH), to afford chiral diastereomerically enriched amines in one pot. The asymmetric reduction of unsaturated ketones and aldehydes by ene reductases from the Old Yellow Enzyme family (OYE) was adapted to reaction conditions for ...