2007年6月22日 · Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A), a member of a novel family of proapoptotic proteins, is expressed abundantly in the brown adipose tissue of the mouse. Although Cidea mRNA is not detectable in the mouse liver, we now show that peroxisome proliferator-activa …

2007年6月22日 · One of the genes identified by microarray analysis, called Cidea, a member of a novel family of cell death-inducing DFFA (DNA fragmentation factor-α)-like effectors (CIDEs) (17, 18, 19, 20), is up-regulated in liver in response to PPARα ligands as well as PPARγ overexpression (12, 16).

2019年10月25日 · Brite adipocytes exhibited elevated UCP1 expression and increased mitochondrial biogenesis along with brite/beige markers. Our studies reveal that during britening CIDEA expression increases and it translocates to the nucleus via a nuclear bipartite signal.

Our study identifies a transcriptional role of cell death-inducing DNA fragmentation factor-like effector A (CIDEA), a lipid-droplet-associated protein, whereby it regulates human adipocyte britening/beiging with consequences for the regulation of energy expenditure.

Zhou et al. found that CIDEA localizes to mitochondria and cooperates with and suppresses the uncoupling activity of UCP1 71. In another study using transgenic aP2-hCidea mice that overexpressed human CIDEA in all adipose tissues, UCP1 activity was significantly inhibited in BAT mitochondria isolated from aP2-hCidea mice 72 .

2003年8月10日 · We show here that Cidea, a protein of unknown function sharing sequence similarity with the N-terminal region of DNA fragmentation factors Dffb and Dffa, is expressed at high levels in BAT....

2015年11月23日 · Expression of PPAR γ, a known regulator of cell death-inducing DFFA-like effector (CIDEA), is modulated by hypoxia inducible factor (HIF-1 α). While the involvement of CIDEA in lipid metabolism...

2007年7月1日 · Cidea (cell death-inducing DNA fragmentation factor alpha-like effector A), a member of a novel family of proapoptotic proteins, is expressed abundantly in the brown adipose tissue of the mouse.

Cidea (cell death-inducing DNA fragmentation factor α-like effector A), a member of a novel family of proapoptotic proteins, is expressed abundantly in the brown adipose tissue of the mouse.

The coordination among LDs, peroxisomes, and mitochondria was regulated by adipocyte triglyceride lipase (ATGL)-peroxisome proliferator-activated receptor α (PPARα). Double deficiency of Cidea and Cidec activated energy consumption in both WAT and BAT, which provided new insights into therapeutic approaches for obesity and diabetes.