A deuterated drug is a small molecule medicinal product in which one or more of the hydrogen atoms in the drug molecule have been replaced by its heavier stable isotope deuterium. …

Deuterated versions of existing drugs can exhibit improved pharmacokinetic or toxicological properties due the stronger deuterium-carbon bond modifying their metabolism. There is great …

2023年6月5日 · In this Review, we highlight key milestones in the field of deuteration in drug discovery and development, emphasizing recent and instructive medicinal chemistry …

2017年11月21日 · Now, this situation has clearly changed with the FDA granting marketing approval for the first deuterated drug molecule, deutetrabenazine (1; a racemic mixture), which …

Introduction: Deuterated versions of existing drugs can exhibit improved pharmacokinetic or toxicological properties due the stronger deuterium- carbon bond modifying their metabolism. …

2019年1月14日 · The use of deuteration in medicinal chemistry has exploded in the past years, and the FDA has recently approved the first deuterium-labeled drug. Precision deuteration …

2022年3月4日 · A deuterated drug comprises diminutive molecules in which deuterium replaces one or more than one hydrogen atoms of the molecule. As deuterium and hydrogen possess …

Deuteration refers to the selective replacement of protium hydrogen isotope atoms in small-molecule drugs with deuterium hydrogen isotope atoms. Deuteration of a drug is most likely to …

Deuterated Anticancer Drug Development Update. Deutetrabenazine is the leading deuterated drug approved by the FDA for the management of chorea and tardive dyskinesia due to …

2024年12月23日 · Deuterated drugs, which are derived from the subtle exchange of a protium atom with a deuterium atom in drug molecules, exhibit significant differences in …