Recent studies highlight a key role for mitochondrial dysfunction in the development and progression of NAFLD. It is proposed that changes in mitochondrial structure and function are …

2024年6月5日 · Using Activator protein 1 (AP1) activity to screen for senescence 14, 15, we determine that senescent glia can appear in response to neuronal mitochondrial dysfunction. …

Furthermore, IR increases hepatic De novo lipogenesis (DNL) and stimulates adipose tissue to secrete adipokine and inflammatory cytokine, ultimately leading to the dysregulation of …

2025年1月7日 · De novo lipogenesis (DNL), the synthesis of new fatty acids from cytosolic acetyl-CoA, is a fundamental physiological process that contributes to metabolic dysfunction …

2018年1月9日 · The transported citrates by these two transporter proteins provide acetyl-CoA precursors for the de novo lipogenesis (DNL) pathway to support a high rate of cancer cell …

2023年5月23日 · We hypothesize that sustained de novo lipogenesis, through its biochemical relationships with mitochondria (e.g., tri-carboxylic acid (TCA) cycle) can contribute to …

2024年1月12日 · The first intervention class targets hepatic fat accumulation by modulating PPARs (i.e., pemafibrate and elafibranor), targeting FXR signaling (i.e., obeticholic acid and …

2024年11月21日 · Mitochondrial dysfunction plays a central role in the pathogenesis of NAFLD. MiRNAs, mtDAMPs, oxidative stress, and lipotoxic responses are all important factors that …

Sedentary lifestyle coupled to hypercaloric diet and genetic background lead to the development of insulin resistance (IR), which causes NAFLD onset. In addition, compensatory …

Luukkonen et al. report that homozygous carriers of the PNPLA3 I148M variant are characterized by hepatic mitochondrial dysfunction as determined by markedly increased ketogenesis and …