The structure of E-cadherin consists of 5 cadherin repeats (EC1 ~ EC5) in the extracellular domain, one transmembrane domain, and a highly-phosphorylated intracellular domain. This …

2013年1月1日 · E-cadherin is among the most important molecules that regulate cell-cell adhesion in epithelial tissues (Gumbiner 2005). E-cadherin is located in regions of cell-cell …

We summarize the structure and regulation of the E-cadherin gene and transcript. Models for E-cadherin-catenin complexes and cell junctions are presented. The structure of the E-cadherin …

Cells of the early ectoderm layer express E-cadherin, and thus adhere together homotypically to form an epithelial cell layer. Some of these cells then “switch” from expression of E-cadherin to …

2015年5月14日 · We report the crystal structure of an E-cadherin extracellular fragment in complex with a peptidomimetic compound that was previously shown to partially inhibit …

Here, we present the high-resolution crystal structure of the N-terminal two domains of human E-cadherin. Comparison of this structure with other type I cadherin structures reveals features …

2020年10月12日 · E-cadherin is a key Ca-dependent cell adhesion molecule, which is expressed on many cell surfaces and involved in cell morphogenesis, embryonic development, EMT, etc. …

2006年12月9日 · Here, we present the high-resolution crystal structure of the N-terminal two domains of human E-cadherin. Comparison of this structure with other type I cadherin …

2021年11月15日 · Regulation of multiple dimeric states of E-cadherin by adhesion activating antibodies revealed through Cryo-EM and X-ray crystallography. E-cadherin adhesion is …

2008年8月23日 · We summarize the structure and regulation of the E-cadherin gene and transcript. Models for E-cadherin-catenin complexes and cell junctions are presented. The …