2021年5月1日 · Inflammation involving TNF-alpha, pro-inflammatory cytokines, MAPK, ERK pathways have been seen in the event of heavy metal hepatotoxicity. All these have shown that these heavy metals pose a serious threat to human health in …

Much heavy metal's viz. Lead, Chromium, Arsenic, Mercury, Nickel, and Cadmium pose a serious threat when they go beyond permissible limits and cause hepatotoxicity. They cause the generation of ROS which in turn causes numerous injuries and undesirable changes in the liver.

2024年4月3日 · The heavy metals such as iron, copper, mercury, tin, lead, zinc, and cadmium are directly toxic to cells and demonstrate hepatotoxicity in vitro. At the typical concentrations of trace and heavy metals in the diet, however, these agents are safe and have not …

Heavy metals exposure has been associated with liver dysfunction in recent reports, while the hepatoxicity of lead (Pb) and cadmium (Cd) has been well established. However, the combined effects of multi-metal in real-world scenario on liver dysfunction are still unclear.

Experimental liver injury with hepatocelluar necrosis and abnormal liver tests is caused by exposure to heavy metals (HMs) like aluminum, arsenic, beryllium, cadmium, chromium, cobalt, copper, iron, lead, mercury, molybdenum, nickel, platinum, thallium, titanium, vanadium, and zinc.

The oxidative stress mediated toxicity of heavy metals involves damage primarily to liver (hepatotoxicity), central nervous system (neurotoxicity), DNA (genotoxicity), and kidney (nephrotoxicity) in animals and humans. Heavy metals are reported to impact signaling cascade and associated factors leading to apoptosis.

2024年8月1日 · Multiple animal experiments have indicated that the inflammatory response may be a critical pathway for hepatotoxicity of heavy metals. For instance, compared to the control group, mice exposed to Pb acetate showed significant increases in IL-1β, TNF-α, and apoptosis factor Bax in the liver (Li et al., 2023a, b).

In our studies, we observed that Zingiber officinale offered some hepatic protection to heavy metal accumulations in the liver, such percentage protections varied with the metal and methodology of exposures.

2023年9月7日 · There are growing calls for the use of essential metals in mitigating the injurious effects induced by heavy metals exposure to man; therefore, the aim of this study was to evaluate the protective effects of essential metals (Zinc and Selenium) in a mixture of heavy metal toxicity.

2023年1月7日 · Numerous experiments have proven that Tau has clear alleviating effects on the damage caused by heavy metals such as cadmium, manganese, and lead. The main mechanisms of action are alleviating oxidative damage, reducing apoptosis, and alleviating the dysfunction of target organs.