2022年1月21日 · The hypoxia cytotoxicity ratio (HCR) is the gold standard for hypoxia-sensitive drugs. Significantly, mil40- 5 showed oxygen concentration-dependent cytotoxicity (Fig. 1b ).

2023年7月12日 · To improve tumor-targeted efficacy, we developed a hypoxia-cleavable, RGD peptide-modified poly(D,L-lactide-co-glycolide) (PLGA) nanoparticle (termed ARNP) for the …

2020年10月10日 · Taking advantage of the specific bioreductive microenvironments in hypoxic tumors, researchers have recently developed several hypoxia-responsive nanoparticles (HR …

2022年12月14日 · Here, we present an enzyme-derived clicking PROTACs (ENCTACs) capable of orthogonally cross-linking two disparate small-molecule warhead ligands that recognize …

cleavable linkers (valine-citrulline linker), all face this nonspecific release problem, 3 because their cleaving enzymes are widely distributed with no significant difference in their quantities

2022年9月16日 · Herein, we synthesized hypoxia-responsive PEGylated (PEG = poly (ethylene glycol)) paclitaxel prodrugs by utilizing azobenzene (Azo) as a cleavable linker. The as …

The hypoxia cytotoxicity ratio (HCR) is the gold standard for hypoxia-sensitive drugs. Significantly, mil40-5 showed oxygen concentration-dependent cytotoxicity (Fig. 1b). In Herceptin-sensitive …

2023年9月1日 · We established fibroblastic foci-targeting and hypoxia-cleavable bovine serum albumin (BSA) nanoparticles (Fn-Azo-BSA@PEG) to reprogramme the fibroblastic foci in …

2025年1月10日 · PAO-L showed higher cellular uptake under hypoxia condition, and significantly inhibited the growth of B16F10 and 4 T1 tumors upon laser irradiation, as well as lung …

2020年6月20日 · A hypoxia-activatable pro-protein and glucose oxidase (GOx) were encapsulated within hypoxia-dissociable nanocomplexes (NCs) to achieve tumor-specific, …