T cell activation and effector function in the human Jurkat T cell ...
In vitro easy-to-handle cellular models are valuable tools to study intracellular molecular mechanisms in live cells. The CD4 T cell line Jurkat (JK) has been widely employed to …
CD4 and CD8 co-receptors modulate functional avidity of CD1b
2022年1月10日 · CD4+ primary T cells transduced with mycolipid-specific T cell receptors bind CD1b-mycolipid tetramer with a higher fluorescence intensity than CD8+ primary T cells. The …
Jurkat细胞模型在感染性疾病研究中的应用进展 - PMC
Wang等 通过Jurkat细胞模型研究发现, HTLV-1 Tax解除对自噬途径和c-FLIP表达的调控, 这两者均有助于抵抗死亡受体介导的细胞凋亡。由全反式维甲酸引起的Tax活化的人Jurkat白血病T细胞 …
Unique roles of co-receptor-bound LCK in helper and cytotoxic T …
2022年12月23日 · Overall, our findings reveal the role of co-receptor-bound LCK in T cell biology, show that CD4- and CD8-bound LCK drive T cell development and effector immune responses …
Relationship between CD8-dependent antigen recognition, T …
We have examined what properties of CD8 can impact T cell function using Jurkat cells expressing high and low affinity human TCRs . In our hands, enhancing the strength of the …
CD4+ and CD8+ TCRβ repertoires possess different potentials …
2016年3月31日 · Fifty-thousand Jurkat 76 or Jurkat 76/CD8 cells expressing one of 11 clonotypic CD8 + T cell-derived TCRβ chains or 15 clonotypic CD4 + T-cell-derived TCRβ chains along …
CRISPR/Cas9-medaited knockout of endogenous T-cell receptor in Jurkat …
2022年9月1日 · In this study, we used the lentiviral delivery of CRISPR/Cas9 for disrupting the expression of the endogenous TCR in the Jurkat cell line. Next, an exogenous TCR targeting …
Frontiers | Using the Jurkat reporter T cell line for evaluating the ...
2023年2月21日 · FiCAR-equipped Jurkat T cells were cytotoxic in cocultures with target cells and target cell engagement lead to an upregulation of CD107a on the Jurkat reporter T cell …
Role of Signal-Transducing Adaptor Protein-1 for T ... - Oxford …
2024年2月5日 · Jurkat cells and murine CD4 + T cells were stimulated with anti-CD3 (6 μg/ml) plus anti-CD28 (2 μg/ml) for the indicated periods. Human and mouse IL-2 levels in …
Jurkat细胞概况 - 哔哩哔哩
Jurkat细胞的特点有. ① 表达CD3、CD4、CD8和CD25等T细胞表面标志物； ② 具有较高的增殖能力，可在体外大量扩增； ③ 能够分泌多种细胞因子，如白介素-2（IL-2）、干扰素-γ（IFN …