Kainic acid, or kainate, is an acid that naturally occurs in some seaweed. Kainic acid is a potent neuroexcitatory amino acid agonist that acts by activating receptors for glutamate, the principal excitatory neurotransmitter in the central nervous system.

Kainic acid (KA) is a potent agonist of AMPA/KA glutamatergic receptors known to induce excitotoxicity, neuronal death and network reorganizations in various areas of the brain.

Kainic acid is a dicarboxylic acid, a pyrrolidinecarboxylic acid, a L-proline derivative and a non-proteinogenic L-alpha-amino acid. It has a role as an antinematodal drug and an excitatory amino acid agonist.

The kainic acid model of temporal lobe epilepsy has greatly contributed to the understanding of the molecular, cellular and pharmacological mechanisms underlying epileptogenesis and ictogenesis. This model presents with neuropathological and ...

Kainic acid, the flagship member of the kainoid family of natural neurochemicals, is a widely used neuro-pharmacological agent that helped unravel the key role of ionotropic glutamate receptors, including the kainate receptor, in the central nervous ...

Kainic acid is a heterocyclic analogue of glutamic acid. Systemic injection of this acid induces generalized partial complex motor seizures, which progressively evolve into status epilepticus in animals.

Kainic acid is a highly potent receptor agonist, and as such in this system, it is a neurotoxin and excitant. Kainic acid is a natural product derived from the red alga Digenea simplex.

Kainic acid (KA), a potent agonist to the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate class of glutamate receptors, is 30-fold more potent in neuro-toxicity than glutamate.

2007年9月28日 · Kainic acid, an acidic pyrolidine isolated from the seaweed Digenea simplex, is the most potent of the commonly used exogenous excitotoxins. The neurotoxic threshold of kainic acid is nearly two magnitudes lower than that of the other receptor-specific agonists, N-methyl-D-aspartic acid and quisqualic acid. Neurophysiological and ligand-binding ...

Kainic acid, an acidic pyrolidine isolated from the seaweed Digenea simplex, is the most potent of the commonly used exogenous excitotoxins. The neurotoxic threshold of kainic acid is nearly two magnitudes lower than that of the other receptor-specific agonists, N-methyl-D …