2016年10月11日 · Myelin is essential to the conduction of nerve impulses in the brain and spinal cord, and myelin loss is a key pathophysiological component of neurological injury and disease, including multiple sclerosis, traumatic brain and spinal cord injury, stroke, and some neuropsychiatric disorders.

2024年4月27日 · In this disease, the immune system attacks the myelin sheath or the cells that produce and maintain it. The attack causes swelling, also known as inflammation, and injury to the myelin sheath. Ultimately, the nerve fibers the myelin sheath surrounds are damaged. The process can result in areas of scarring, known as sclerosis. Other causes

2024年11月1日 · In multiple sclerosis, the protective coating on nerve fibers, known as myelin, in the central nervous system is damaged. Depending on the location of the damage in the central nervous system, symptoms may happen, including numbness, tingling, weakness, visual changes, bladder and bowel troubles, memory troubles, or mood changes, for example.

2024年1月3日 · Myelin oligodendrocyte glycoprotein antibody-associated disease, also known as MOGAD, is a rare inflammatory disease that affects the central nervous system. In MOGAD , the immune system attacks the fatty substance that protects nerve fibers in the optic nerves, brain and spinal cord.

2022年1月19日 · Transverse myelitis is an inflammation of both sides of one section of the spinal cord. This neurological disorder often damages the insulating material covering nerve cell fibers (myelin). Transverse myelitis interrupts the messages that …

In multiple sclerosis, the protective coating on nerve fibers, known as myelin, in the central nervous system is damaged. Depending on the location of the damage in the central nervous system, symptoms may happen, including numbness, tingling, weakness, visual changes, bladder and bowel troubles, memory troubles, or mood changes, for example.

2024年1月3日 · Sechi E, et al. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of clinical and MRI features, diagnosis, and management. The Frontiers in Neurology. 2022; doi:10.3389/fneur. 2022.885218 .

2022年5月25日 · "The study connects obesity, which is a known risk factor for developing MS, with a metabolic pathway that can be therapeutically targeted to enhance myelin regeneration." The research focused on altered NAD+ metabolism, which has been linked to both high fat consumption and MS. Previous studies have described increased expression of CD38 ...

2024年6月7日 · In Guillain-Barre syndrome, your immune system — which usually attacks only invading organisms — begins attacking the nerves. In AIDP, the nerves' protective covering, known as the myelin sheath, is damaged. The damage prevents nerves from transmitting signals to your brain, causing weakness, numbness or paralysis.

2020年3月6日 · The most common cause of metachromatic leukodystrophy is a mutation in the ARSA gene. This mutation results in a lack of the enzyme that breaks down lipids called sulfatides that build up in the myelin. Rarely, metachromatic leukodystrophy is caused by a deficiency in another kind of protein (activator protein) that breaks down sulfatides.