2021年8月18日 · Over the past few decades, long acting injectable (LAI) depots of polylactide-co-glycolide (PLGA) or polylactic acid (PLA) based microspheres have been developed for controlled drug delivery to reduce dosing frequency and to improve the therapeutic effects.

Many companies have unsuccessfully attempted to develop a generic product of PLGA micropsheres, mainly by starting with the same type of polymer and altering the manufacturing process e.g. using...

2024年10月31日 · Researchers have explored the therapeutic benefits of using PLGA microspheres loaded with diclofenac, an anti-inflammatory drug, to effectively manage the symptoms of rheumatoid arthritis. The study demonstrated promising outcomes, showcasing the efficacy of PLGA microspheres in disease management.

Poly(lactic-co-glycolic acid) (PLGA) microspheres are a sustained-release drug delivery system with sev-eral successful commercial products used for the treatment of a variety of diseases. By utilizing PLGA polymers with different compositions, therapeutic agents can be released over durations varying from several weeks to several months.

PLGA and PLA polymers are FDA-approved biodegradable and biocompatible polymers that have been used in medical devices, including microspheres. PLA and PLGA microspheres are widely studied polymers in the medical field, as they allow for the encapsulation of the desired active pharmaceutical ingredient or drug.

2024年8月30日 · In this study, we developed an effective method that combines microfluidics with interfacial instability to prepare monodispersed poly (lactic- co -glycolic acid)- b -polyethylene glycol (PLGA-PEG)/poly (lactic- co -glycolic acid) (PLGA) …

2018年6月9日 · In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparticles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS.

In this review, we present some recent achievement of the PLGA/PLA microspheres/nanoparti-cles, and discuss some promising manufacturing methods. Finally, we focus on the current FDA guidance on the DDS. The review provides an overview on the develop-ment of the system in pharmaceutical industry.

Recently, PLGA-based microspheres have attracted exceptional attention relating to effective drug delivery systems (DDS) because of their distinctive properties for a simple preparation, biodegradability, and high capability of drug loading which might be increased drug delivery.

PLGA microspheres are administered by subcutaneous or intramuscular injec-tion to create a localized depot of drug at the target site. It is important that the microspheres are of a sufficient size, usually on the microscale to form the depot and avoid migration to non-target tissue. In general, microsphere size is a critical