Propranolol is a racemic mixture of 2 enantiomers where the S(-)-enantiomer has approximately 100 times the binding affinity for beta adrenergic receptors. Propranolol is used to treat a number of conditions but most commonly is used for hypertension.

2025年1月1日 · In this work, a new thiol-maleimide-based molecular imprinting strategy has been developed to achieve enantioselective recognition and separation of propranolol enantiomers. This method presents an important advance in view of the structural precision provided by MIP technology in combination with the efficiency of the thiol-maleimide reaction ...

2017年4月20日 · Propranolol is a racemic mixture of two enantiomers, R (+) and S (−). The S-enantiomer is approximately 100 times as potent as the R (+)-enantiomer in blocking beta adrenergic receptors. The interaction of opposite enantiomer of a drug with living organism is …

2014年12月5日 · Enantiomeric recognition of Propranolol by complexation with β-Cyclodextrin was studied by PM3 method and molecular dynamics (MD) simulation. Gas phase results show that the R-enantiomer complex is more stable than the S-enantiomer complex by 8.54 kJ/mol (Hartree–Fock energy).

2000年1月26日 · In this work the structural basis for enantioselectivity of basic drugs by Cel7A has been studied by X-ray crystallography. The catalytic domain of Cel7A was co-crystallised with the (S)-enantiomer of a common beta-blocker, propranolol, at pH 7, and the structure of the complex was determined and refined at 1. 9 A resolution.

2017年1月11日 · In this study, 3- (trimethoxysilyl)propyl methacrylate (γ-MPS), a bifunctional group compound, was used as a single cross-linking agent to prepare molecular imprinted inorganic–organic hybrid polymers by in situ polymerization for open-tubular capillary electro chromatography (CEC) column.

2023年3月22日 · Propranolol enantiomers: Propranolol has two enantiomers, S (-) and R (+), which have different pharmacological properties. The S (-) enantiomer is the active form of Propranolol and has higher beta-blocking activity compared to the R (+) enantiomer.

Using SWV, the AgNP-IL-FG-NF/GCE sensor showed a linear response from 79 nmol L−1 to 2.9 μmol L−1 for SAL and from 0.1 to 2.9 μmol L−1 for PRO with limits of detection of 13 and 17 nmol L−1 for SAL...

fects because the organism serves as a chiral selector. Enantiomers can now be identified and separated using analytical techniques such as gas ch. omatography and high-performance liquid...

2023年1月1日 · Enantiomers can now be identified and separated using analytical techniques such as gas chromatography and high-performance liquid chromatography. The nonselective b-adrenergic blocker...