Microvesicles are a heterogeneous group of membrane‐enclosed vesicles that are released from cells into the extracellular space by the outward budding and pinching of the plasma membrane. These vesicles are loaded with multiple selectively sorted proteins and nucleic acids.

Three selectins, E-selectin, P-selectin, and L-selectin, play distinct, complementary roles in inflammation, hematopoiesis, and tumor biology. They have been implicated in the pathology of diverse inflammatory disorders, and several selectin antagonists have been tested clinically.

At present they are best studied in tumor cells, and frequently include selectins, flotillin-2, ARF6 and CD40. 3,102 As indicated above, an ever-evolving body of work reveals that many of these markers may not be exclusive to a particular class of vesicle, 36 underscoring the heterogeneity of EVs and the potential overlap in functions between ...

2020年9月14日 · It has been reported that larger ExMVs derived by cell membrane budding express CD40, selectins, integrins, and cytoskeletal proteins, and their membranes are highly enriched in cholesterol ...

2023年4月21日 · Microvesicles are cellular membrane vesicles of which size is limited to 30–1000 nm. Almost all cells release them in response to activation signals and apoptosis. Their ability for intercellular communication and enhancement of potential for information exchange (between them) has attracted much interest.

2017年6月7日 · When activated platelets attach to neutrophils via P-selectin-PSGL-1 mediated binding, neutrophils extracellular vesicles (microvesicles or microparticles) are released that are involved in a multistep reciprocal crosstalk between platelets and neutrophils.

2021年3月4日 · Microvesicles are a heterogeneous group of membrane-enclosed vesicles that are released from cells into the extracellular space by the outward budding and pinching of the plasma membrane. These vesicles are loaded with multiple selectively sorted proteins and …

CD162 (P-selectin-binding glycoprotein [PSGL-1]) plays a critical role in leukocyte trafficking during inflammation by being responsible for the interaction between leukocytes and activated platelets or endothelial cells that express selectins; therefore, CD162 is considered a marker of leukocyte-platelet interactions [13].

2021年2月11日 · In this study, we analysed the capacity of the differential centrifugation method to isolate MVs from cell-conditioned medium using flow cytometry and TEM/AFM microscopy. We found that the loss of...

The interaction between PSGL-1 on monocyte-derived microvesicles and selectins on platelets, endothelial cells or their shed microvesicles provides a basis for thrombus formation . Angiogenesis. Microvesicles derived from blood and endothelial and tumor cells may possess angiogenic properties, as previously reviewed . The angiogenic effect may ...