2018年9月17日 · Performing SLCO1B1 testing led to an increased willingness by providers to reinitiate statins and improved patient perceptions of statin therapy. This translated into a 20 …

Several polymorphisms in SLCO1B1, the gene encoding the SLCO1B1, result in altered transport of statins and their metabolites into the liver. It is within hepatocytes that statins exert their lipid …

We confirmed the association of SLCO1B1 c.521C/C genotype with simvastatin intolerance both by using phenotype of switching initial statin to another as a marker of statin intolerance …

SNPs in cytochrome P450 enzymes impair statin metabolism; the reduced function SLCO1B1*5 allele impairs statin clearance and is associated with simvastatin-induced myopathy with CK …

2018年9月17日 · In a prospective randomized controlled trial, we found that compared with UC, addressing statin toxicity through pharmacogenetic testing (1) did not affect self-reported statin …

2008年8月21日 · We have identified common variants in SLCO1B1 that are strongly associated with an increased risk of statin-induced myopathy. Genotyping these variants may help to …

2009年11月3日 · In this review we explore current literature regarding the pharmacokinetic and pharmacodynamic influence of the common c.388A>G and c.521T>C single-nucleotide …

2022年10月3日 · We carried out retrospective multiple linear regression analysis using robust standard errors of 129 individuals undergoing genetic testing for the SLCO1B1 polymorphisms …

1 天前 · These include recommendations stratified by genotype and drug for both SLCO1B1-statin and CYP2C9-sulfonylurea gene-drug interactions, annotations of genetic variants and their …

2024年12月15日 · Statins, including simvastatin, atorvastatin, rosuvastatin, fluvastatin, and pravastatin, reduce the risk of cardiovascular events by decreasing circulating low-density …