Stress granules (SGs) are formed in response to acute biotic and abiotic stress. Stressors include, but are not limited to, toxicity exposure, oxidative stress, viral infections, nutrient depletion, and irradiation. 1 The cell responds to these stressors by interrupting

Besnard-Guérin, C. Cytoplasmic localization of amyotrophic lateral sclerosis-related TDP-43 proteins modulates stress granule formation. Eur J Neurosci. 2020;52:3995–4008 Blechingberg, J., Luo, Y., Bolund, L., et al. Gene Expression Responses to FUS, EWS, and TAF15 Reduction and Stress Granule Sequestration Analyses Identifies FET-Protein ...

Stress granules (SGs) are small membrane-free cytosolic liquid-phase ordered entities in which mRNAs are protected and translationally silenced during cellular adaptation to harmful conditions...

Stress granules (SGs) are distinct RNA granules induced by various stresses, which are evolutionarily conserved across species. In general, SGs act as a conservative and essential...

Download scientific diagram | Stress granule (SG) formation via the eIF2α-mediated pathway. When cells are under stress, protein kinase R (PKR) is activated and phosphorylated....

Analysis of mammalian stress granules has revealed they are comprised of two phases: a less concentrated shell, which disassembles upon cell lysis and thus behaves like a LLPS formed by weak interactions; and more stable, internal 'core' structures (Jain et al., 2016).

2016年9月7日 · Stress granules (SGs) are an important cellular defense mechanism against stress. Their formation is a transient response to cellular stress and the granules normally disassemble after the stress is removed. However, when SG degradation is disrupted, toxic protein aggregates can accumulate.

2017年4月1日 · Key features of SGs and related cytoplasmic RNA granules. The continuous or stress-induced granule formation is indicated. Microtubules are implicated in the biology of all the granules listed. They contain mRNA and translation factors, but diverge with respect to the presence of ribosomal subunits and signaling kinases.

Stress granules (SGs) are dynamic membrane-less condensates transiently assembled through liquid–liquid phase separation (LLPS) in response to stress. SGs display a biphasic architecture...

Stress granules are thought to form by protein–protein interactions of RNA-binding proteins. We demonstrate RNA homopolymers or purified cellular RNA forms assemblies in vitro analogous to stress granules.