An uncoupling protein (UCP) is a mitochondrial inner membrane protein that is a regulated proton channel or transporter. An uncoupling protein is thus capable of dissipating the proton gradient generated by NADH -powered pumping of protons from the mitochondrial matrix to the mitochondrial intermembrane space.

In this review, we first compare the mitochondrial uncoupling agents available in term of mechanistic and non-specific effects. Proteins regulating mitochondrial uncoupling, as well as chemical compounds with uncoupling properties are discussed.

An Uncoupling Protein is a mitochondrial transporter found in the inner membrane of mitochondria that plays a role in the dissipation of oxidation energy into heat, thereby regulating cellular metabolism and free radicals levels.

2002年3月12日 · The uncoupling proteins (UCPs) are transporters, present in the mitochondrial inner membrane, that mediate a regulated discharge of the proton gradient that is generated by the respiratory chain.

In contrast to basal leak, which is unregulated, uncoupling proteins can catalyze inducible proton leak that is sensitive to inhibitors. UCP1 was the first identified uncoupling protein, and mediates non-shivering thermogenesis by brown adipose tissue (BAT) (Ricquier and Bouillaud, 2000; Nicholls, 2001).

2004年2月1日 · Uncoupling proteins (UCPs) are mitochondrial transporters present in the inner membrane of mitochondria. They are found in all mammals and in plants. They belong to the family of anion mitochondrial carriers including adenine nucleotide transporters.

2005年3月1日 · Uncoupling protein (UCP)1 is an integral membrane protein that is located in the mitochondrial inner membrane of brown adipocytes. Its physiological role is to mediate a regulated,...

The uncoupling proteins are proton channel proteins on the inner mitochondrial membrane and uncouple oxidative phosphorylation by converting the electrochemical potential of the mitochondria into heat instead of ATP.

Found in most eukaryotes, uncoupling proteins (UCPs) are membrane-intrinsic proteins that compete with the F 1 Fo-ATP synthase (complex V) for the proton–electron gradient established by the activity of complexes I, III, and IV.

Uncoupling proteins are mitochondrial carrier proteins which are able to dissipate the proton gradient of the inner mitochondrial membrane. This uncoupling process reduces the amount of ATP generated through an oxidation of fuels.