Gene therapy helps weak mice grow strong | Science - AAAS
2014年9月18日 · The Tokyo group gave the treatment to mice with a rodent form of Emery-Dreifuss muscular dystrophy (EDMD), an inherited disease in humans involving a defect in a …
Inbreeding and Genetic Weakening - G.W. Deer Mouse Ranch
Genetic weakening occurs with mice raised in a safe (captive) environment. When mice are protected from the natural culling of the wild, genetically "weak" mice survive long enough to …
Health Evaluation of Experimental Laboratory Mice - PMC
Severely dehydrated mice will be weak and often will look paralyzed in their rear legs. These mice may also have trouble gripping the cage bars with their forefeet. Other symptoms of severe …
Heterogeneity, a weak link between constrained dose of AAV and …
2024年12月31日 · Yue et al examined the female carrier mice generated from crossbreeding of 313 mdx and C57BL/10 mice.77 These mice express the full-length dystrophin gene in about …
Guidelines for Assessing the Health and Condition of Mice
1998年11月30日 · Increased numbers of mice—some with potentially debilitating phenotypes—are being maintained to their natural life spans, and this has chal- lenged the …
Mice in Microgravity Help Patients on Earth
2023年2月27日 · The investigation featured 40 female mice, which included normal (or wild-type) mice, wild-type mice treated with an agent that inhibits myostatin and activin A, and genetically …
Deletion of TNF-Like Weak Inducer of Apoptosis (TWEAK) Protects Mice …
To investigate the role of TNF-like weak inducer of apoptosis (TWEAK) in pathological adipose tissue (AT) remodeling and complications of obesity. Wild type (WT) and TWEAK knockout …
Weak Epistasis Generally Stabilizes Phenotypes in a Mouse …
To mitigate this limitation, we analyzed bone and body composition traits in an unusually large mouse intercross population of over 2000 mice, paired with a recently-developed …
Depressed neuromuscular transmission causes weakness in mice ... - PubMed
2020年5月4日 · Our work demonstrates that mice lacking BK channels have weakness due to a defect in vesicle release at the NMJ. Mice lacking functional large-conductance voltage- and …
Mouse Model of Weak Depression Exhibiting Suppressed cAMP …
2022年5月19日 · To establish a mouse model of weak depression, we raised 6-week-old C57BL/6N mice in single (SH) or group housing (GH) conditions for 2 weeks. The SH group …