Acetyl-CoA is a metabolic intermediate that is involved in many metabolic pathways in an organism. It is produced during the breakdown of glucose, fatty acids, and amino acids, and is …

2024年6月5日 · Acetate and citrate, in turn, can be used to generate nuclear acetyl-CoA by acetyl-CoA synthase (AcCoAS/ACSS2) or ATP citrate lyase (ATPCL/ACLY). Nuclear acetyl …

The end products of the PHC oxidative decarboxylation reaction are the two-carbon acetyl-CoAs, NADH, and CO 2. The acetyl-CoA then enters a cyclic, non-linear pathway called the citric …

2024年1月18日 · The main sites of acetyl-CoA production in the cell are the mitochondria, where it is produced by the pyruvate dehydrogenase (PDH) using pyruvate molecules generated by …

Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic pathways and transformations. Emerging evidence reveals that cells monitor the levels of …

2019年3月26日 · Here we design and construct a Synthetic Acetyl-CoA (SACA) pathway by repurposing glycolaldehyde synthase and acetyl-phosphate synthase. First, we design and …

ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl-CoA, a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM …

2024年3月7日 · Our findings indicate that the local supply of acetyl-CoA generated by 2-ketoacid dehydrogenases bound to Mediator is required to maximize acetylation of histone tails at sites …

2019年12月23日 · ATP-citrate lyase (ACLY) is the predominant source of nucleocytosolic acetyl coenzyme A (acetyl-CoA), an essential building block for the production of fatty acids,...

In this study, we report that nuclear ATP-citrate lyase (ACLY) is phosphorylated at S455 downstream of ataxia telangiectasia mutated (ATM) and AKT following DNA damage. ACLY …