Cryo-EM Unveils Distinct Aβ42 Fibril Structures for ... - ALZFORUM
2022年1月14日 · Cryo-EM of Aβ42 fibrils from 10 brains revealed two predominant filament structures. Type I and type II filaments comprised distinct, S-shaped protofilaments. Type I …
Catch and Release: Cryo-EM Reveals How LRP2 Receptor
2023年2月10日 · Suspecting that changes in pH could drive the switch, first author Andrew Beenken and colleagues used cryo-EM to solve and compare the structures of LRP2 isolated …
Cryo-EM Developers Win Nobel Prize in Chemistry - ALZFORUM
The Nobel Prize for cryo-electron microscopy honors the development of and recent breakthroughs that have been achieved by this extremely powerful structural biology …
Cryo-EM Resolves Two Aβ40 Fibril Structures Amplified from
2023年1月20日 · Later, researchers led by Michel Goedert and Sjors Scheres of the MRC Laboratory of Molecular Biology, Cambridge, England, U.K., used cryo-EM to solve the …
CryoEM of CBD Tau Suggests Another Unique Protofibril
2020年2月20日 · Moreover, the cryo-EM structures of tau filaments from a case of PiD (Falcon et al., 2018) were prepared with pronase, whereas pronase was not used in the preparation of …
Cryo-EM structure of Alzheimer disease tau filaments with
2023年9月28日 · Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Acta Neuropathol. 2021 May;141(5):697-708. Epub 2021 Mar 16 PubMed. …
Spooned by a Fold: MK-6240 Nestles Within Tau Protofilament
2023年9月28日 · Cryo-EM revealed characteristic AD paired helical filaments (PHFs), with their stacks of back-to-back C-shaped protofilaments. In samples incubated with the tracer, each C …
Tau Filaments Found Tethered Inside Alzheimer's Brain Exosomes
2023年5月12日 · The authors beautifully show the structure of PHF by cryo-electron tomography and single-particle cryo-EM, which also revealed the structure of PHF as two C-shaped …
Conformers Confirmed: Structure of Pick’s Tau Distinct
2018年8月31日 · Cryo-electron microscopy (cryo-EM, aka electron cryomicroscopy) has become the go-to tool for determining the molecular architecture of alternatively folded proteins in …
Flock of New Folds Fills in Tauopathy Family Tree - ALZFORUM
2021年10月5日 · Cryo-EM map of a tau fibril taken from a PSP patient. [Courtesy of Shi et al., Nature, 2021.] Except for a distinct structure in one PSP-F patient, Shi identified the exact …