The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics.

By definition, all β-lactam antibiotics have a β-lactam ring in their structure. The effectiveness of these antibiotics relies on their ability to reach the PBP intact and their ability to bind to the PBP.

2023年6月4日 · The beta-lactam ring stands alone and not fused to another ring. Beta-lactamase inhibitors. They work primarily by inactivating serine beta-lactamases, which are enzymes that hydrolyze and inactivate the beta-lactam ring (especially in gram-negative bacteria).

The structural characteristics of a β-lactam ring provide higher reactivity for β-lactam antibiotics to inactivate penicillin-binding proteins (PBPs) than a linear, five- or six-membered ring and stable benzene ring with conjugated double bonds.

Resistance to β-lactams is primarily because of bacterially produced β-lactamase enzymes that hydrolyze the β-lactam ring, thereby inactivating the drug. The newest effort to circumvent resistance is the development of novel broad-spectrum β-lactamase inhibitors that work against many problematic β-lactamases, including cephalosporinases ...

The β-lactams are the most widely used class of antibiotic. 1,2 The antibiotics in this group are characterized by a reactive four-membered β-lactam ring, which is essential to their bactericidal activity. 3 This β-lactam ring is generally fused with another heterocycle, and this bicyclic core is functionalized in several key positions ...

2012年2月3日 · The β-lactam ring is considered the central motif of the main drugs utilized for the treatment of several bacterial infections such as ampicillin and amoxicillin [14]. The development of efficient and direct methodologies for the synthesis of β-lactams is highly desirable [15–33].

Beta-lactamases are a diverse class of enzymes produced by bacteria that break open the beta-lactam ring, inactivating the beta-lactam antibiotic. Some beta-lactamases are encoded on mobile genetic elements (eg, plasmids); others are encoded on chromosomes.

2024年11月23日 · The β-lactam ring is part of the core structure of several antibiotic families, the principal ones being the penicillins, cephalosporins, carbapenems, and monobactams, which are, therefore, also called β-lactam antibiotics.

A four-membered lactam ring, known as a β-lactam ring, is a common structural feature of this class (see below). To this day, the pharmacology of beta-lactam antibiotics has clearly bore out an excellent safety and efficacy profile.