2023年9月5日 · BILIRUBIN SYNTHESIS. Conversion of heme to bilirubin; Binding of bilirubin to plasma albumin; METABOLISM OF BILIRUBIN. Hepatic uptake and storage; Conjugation of bilirubin; EXCRETION OF CONJUGATED BILIRUBIN. Active transport into the bile; Degradation of bilirubin in the digestive tract; Alternative pathways of bilirubin elimination ...

2022年10月24日 · FORMATION OF BILIRUBIN. Bilirubin is formed by breakdown of heme present in hemoglobin, myoglobin, cytochromes, catalase, peroxidase and tryptophan pyrrolase.

2023年9月5日 · Conjugated bilirubin reacts rapidly ("directly") with the reagents. The measurement of unconjugated bilirubin requires the addition of an accelerator compound and is often referred to as indirect bilirubin.

Several different inherited disorders are characterized by impaired elimination of conjugated bilirubin, with or without impaired excretion of other organic anions. They are caused by pathogenic variants in the following genes : Dubin-Johnson syndrome – ABCC2 (see 'Dubin-Johnson syndrome' below)

2023年9月5日 · Conjugated bilirubin reacts rapidly ("directly") with the reagents. The measurement of unconjugated bilirubin requires the addition of an accelerator compound and is often referred to as indirect bilirubin.

Schematic diagram demonstrating the production, metabolism, and excretion of bilirubin. *Physiologic mechanisms that reduce the movement of free bilirubin across the blood-brain barrier include binding to plasma albumin and rapid uptake, conjugation, and clearance by the liver.

2023年9月5日 · The UGT1A gene that encodes the enzyme UGT1A1 is responsible for the conjugation of bilirubin with glucuronic acid, converting the bilirubin into a water-soluble form that is readily excreted in bile . (See "Bilirubin metabolism".)

The metabolism of bilirubin by the liver is comprised of four distinct but interrelated stages (see "Bilirubin metabolism"): Uptake from the circulation Intracellular storage Conjugation with glucuronic acid Biliary excretion

2023年9月12日 · Jaundice and asymptomatic hyperbilirubinemia are common clinical problems that can be caused by a variety of disorders, including bilirubin overproduction, impaired bilirubin conjugation, biliary obstruction, and hepatic inflammation.

BIND occurs when unconjugated bilirubin that is not bound to albumin (also referred to as "free" or "unbound bilirubin" [UB]), crosses the blood-brain barrier, enters the brain, and causes neurologic injury . Neuronal damage affects several areas of the brain, including the pontine brainstem oculomotor nuclei globus pallidus, auditory pathways ...