2020年12月22日 · We measure CSF production by placing a catheter in a lateral ventricle, while physically blocking outflow from the 4 th ventricle. Using this methodology, we show that CSF production increases during isoflurane anesthesia, and to a lesser extent with ketamine/xylazine anesthesia, relative to the awake state.

2016年7月8日 · We investigated the transport of cerebrospinal fluid in the third ventricle of the mouse brain and discovered a highly organized pattern of cilia modules, which collectively give rise to a network of fluid flows that allows for precise transport within this ventricle.

2023年8月24日 · Recent evidence suggests that the exchange of the cerebrospinal fluid (CSF) with the parenchymal interstitial fluid (ISF) occurs via a highly regulated, brain-wide pathway 1.

2017年11月10日 · We have elucidated a complex flow pattern of CSF after ventricular infusion of tracers in mice, demonstrating various perineural outflow routes from the mouse cranial cavity, as well as...

2022年2月2日 · We developed HEAP-METRIC PC-MRI to allow noninvasive and whole brain mapping of low-velocity CSF flow in the mouse brain. We found directional and regionally heterogeneous CSF flow at a whole-brain average velocity of 216 µm/s in awake mice.

We measure CSF production by placing a catheter in a lateral ventricle, while physically blocking outflow from the 4 th ventricle. Using this methodology, we show that CSF production increases during isoflurane anesthesia, and to a lesser extent with ketamine/xylazine anesthesia, relative to the awake state.

2019年12月30日 · CSF is rich in cytokines, growth factors and extracellular vesicles that glide along the walls of ventricles, powered by bundles of motile cilia that coat the ventricular wall. We review the cellular and biochemical properties of the ventral part of the third ventricle that is surrounded by the hypothalamus.

In this study, we investigated how the tilt angle, quantity, and phase relationship of cilia affect CSF flow patterns in the brain ventricles of zebrafish embryos.

2022年2月1日 · Using this novel method, we provide the first report of whole-brain CSF flow in the awake mouse brain with an average flow velocity of ~200 µm/s. Furthermore, HEAP-METRIC PC-MRI...

Cerebrospinal fluid (CSF) is produced by the choroid plexus in the lateral and 4th ventricles in the brain (See Figure 1) and is similar in composition to serum, the fluid portion of the blood. CSF circulates throughout the ventricular system of the brain.