The sphingolipid ceramide is the main culprit that combines a plethora of nutrients (e.g., saturated fatty acids) and inflammatory cytokines (e.g., TNFα) to the progression of insulin resistance. The accumulation of sphingolipid ceramide in tissues of obese humans, rodents and Western-diet non-human primates is in line with diabetes ...

2017年1月23日 · Our analysis suggests the pivotal role of ceramide synthase, serine palmitoyltransferase and dihydroceramide desaturase involved in the de novo synthesis and the salvage pathways in influencing...

2019年8月21日 · The sphingolipid ceramide is the main culprit that combines a plethora of nutrients (e.g., saturated fatty acids) and inflammatory cytokines (e.g., TNFα) to the progression of insulin resistance. The accumulation of sphingolipid ceramide in tissues of obese humans, rodents and Western-diet non-human primates is in line with diabetes ...

2020年2月14日 · Increased levels of ceramides during obesity contribute to cellular dysfunction in key metabolic tissues, which results in insulin resistance. The synthesis of ceramides with varying acyl...

2006年1月1日 · The sphingolipid ceramide is a putative intermediate linking both excess nutrients (i.e. saturated fatty acids) and inflammatory cytokines (e.g. tumor necrosis factor-α, TNFα) to the induction of insulin resistance. Moreover, ceramide has been shown to be toxic in a variety of different cell types (e.g. pancreatic β-cells, cardiomyocytes ...

It is becoming increasing apparent that ceramide plays significant role in insulin resistance, a metabolic state in which cells fail to respond to the normal hormonal actions of insulin. Evidence from various studies revealed that excess FFA intake, glucocorticoid administration, obesity, and lack of physical exercise are some of the important ...

2012年5月2日 · Studies using cultured cells and isolated muscles revealed that endogenous ceramides and glucosylceramides antagonize insulin-stimulated glucose uptake and anabolism, and thus could mimic the effects of exogenous sphingolipid analogs.

2014年11月4日 · C16:0-ceramide induces insulin resistance by antagonizing insulin receptor (IR)-stimulated PI3K/Akt signaling, which attenuates glucose metabolism. In addition, Akt normally stimulates lipid metabolism by SREBP-dependent mechanisms, which would presumably be inhibited, although not directly investigated in the current manuscripts.

The HIF-2α—NEU3—ceramide pathway can promote the development of metabolic diseases, such as NAFLD, obesity, and insulin resistance. Ceramides are synthesized through three different pathways: De novo pathway, sphingomyelinase (SMase) pathway, and salvage pathway. Increased levels of ceramide cause obesity, insulin resistance, and hepatic ...

The sphingolipid ceramide is a putative intermediate linking both excess nutrients (i.e. saturated fatty acids) and inflammatory cytokines (e.g. tumor necrosis factor-alpha, TNFalpha) to the induction of insulin resistance. Moreover, ceramide has been shown to be toxic in a variety of different cell types (e.g. pancreatic beta-cells ...