Chimeric antigen receptors (CARs) are a new class of drugs with great potential for cancer immunotherapy. Upon their expression in T lymphocytes, CARs direct potent, targeted …

2018年3月31日 · CAR 以抗原依赖、非 MHC（Major histocompatibility complex) 限制的方式结合肿瘤抗原, 这使得经过 CAR 改造的 T 细胞相较于天然 T 细胞表面受体 TCR 能够识别更广泛的 …

Adoptive transfer of T cells collected from autologous peripheral blood and engineered to express chimeric antigen receptors (CARs) has produced impressive clinical responses in patients with …

2024年3月11日 · Background: Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their …

Another approach to adoptive T cell therapy is to engineer T cells to express chimeric antigen receptors (CARs) 16,17. CARs are made up of an antigen-recognizing receptor coupled to …

2019年3月15日 · T cells engineered with chimeric antigen receptors (CARs) have emerged as a potent new class of therapeutics for cancer, based on their remarkable potency in blood …

2024年3月11日 · Chimeric antigen receptor-T (CAR-T) cells therapy is one of the novel immunotherapeutic approaches with significant clinical success. However, their applications …

2021年9月6日 · Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic agents, generating remarkable responses in the clinic for a subset of human …

2023年4月21日 · Here, we implemented the modular recombination strategy to construct a library of CARs with synthetic co-signaling modules adopted from immunoglobin-like superfamily …

2019年3月15日 · Adoptive transfer of T cells collected from autologous peripheral blood and engineered to express chimeric antigen receptors (CARs) has produced impressive clinical …