Interstitial cystitis: possible cause and clinical study of sodium cromoglycate. Interstitial cystitis: possible cause and clinical study of sodium cromoglycate Br J Urol. 1986 Feb;58(1):95-6. doi: 10.1111/j.1464-410x.1986.tb05433.x. ... Cromolyn Sodium ...

2012年12月1日 · Other agents that have been used for intravesical treatment of IC include silver nitrate, Clorpactin, cromolyn sodium, sodium bicarbonate, resiniferatoxin, and Bacillus Calmette–Guerin (BCG) vaccine. However, resiniferatoxin and BCG should not be offered to patients because the two drugs did not show efficacy in well-controlled trials [54], [55].

We further treated URO-OVA mice with cromolyn, a mast cell membrane stabilizer, and found that cromolyn treatment reversed bladder inflammation and LUTD in the animal model. Our results provide direct evidence for the role of mast cells in cystitis-associated LUTD, supporting the use of mast cell inhibitors for treatment of certain forms of IC/BPS.

Interstitial cystitis or bladder pain syndrome (IC/BPS) is a chronic pelvic pain syndrome related to the urinary bladder. The ideal treatment should match as much as possible with the pathophysiologic causes of the IC/BPS, but the scarcely available ...

2016年12月21日 · However, after mast cell reconstitution URO-OVA/KitW-sh mice restored the ability to develop bladder inflammation and LUTD following cystitis induction. We further treated URO-OVA mice with cromolyn, a mast cell membrane stabilizer, and found that cromolyn treatment reversed bladder inflammation and LUTD in the animal model.

2024年4月24日 · Current research suggests that a combination of therapies may have a positive clinical outcome for patients with IC, despite the fact that treatment for this condition is not straightforward. PROSPERO CRD42022384024.

1994年2月1日 · STANDARD INTRAVESICAL THERAPIES FOR INTERSTITIAL CYSTITIS 81 Intravesical disodium cromoglycate (cromolyn sodium), a mast cell inhibitor, showed promise in an early study, with amelioration of symptoms in six of nine patients."

2020年8月31日 · three concepts: cromolyn sodium; oral, nasal, mucosal, or topical administration or form; therapeutic or preventative use for allergy, asthma, or bronchospasm (refer to Appendix 1 for full search strategies).

2011年6月1日 · In the algorithm the panel identifies an overall management strategy for the interstitial cystitis/bladder pain syndrome patient. Diagnosis and treatment methodologies can be expected to change as the evidence base grows in the future.

An experiment was designed to test the effect of sodium cromoglycate on rat bladders. The results are discussed in relation to the management of patients with interstitial cystitis. Twenty histologically proven cases of interstitial cystitis were investigated in an attempt to find evidence of a possible autoimmune mechanism in its aetiology.