ERK是extracellular regulated protein kinases的英文缩写，指细胞外调节蛋白激酶，包括ERK1和ERK2，是将信号从表面受体传导至细胞核的关键。许多其他信号通路明显活化时，可活化蛋白激酶ERK信号通路，ERK明显活化时，也可活化其他信号通路。

2020年6月23日 · ERK can passively diffuse through its interaction with nuclear pore complex (NPC) subunits. ERK can also be actively transported by a RAN–importin-7 (Imp7)-dependent mechanism.

Explore the ERK pathway and its role in cell proliferation and survival. Click here to read more about this critical signaling pathway.

mapk/erk通路又称ras-raf-mek-erk通路，是细胞中可将细胞表面受体的信号传递给细胞核内的dna的蛋白链。 该通路囊括了多种蛋白质，包括丝裂原活化蛋白激酶（MAPK，最初称为ERK），通过在邻近蛋白上添加磷酸基团进行通讯，该蛋白作为“开启”或“关闭”的开关。

丝裂原活化蛋白激酶（mapk）级联是调节细胞多种生理过程的关键信号通路，包括增殖、分化、凋亡和应激反应。 在真核细胞中已经确定了以下四条MAPK级联途径：ERK、JNK、p38 MAPK和ERK5信号转导途径。

ERK pathway upstream protein and kinase activation mechanism. Multiple stimulants such as growth factors, cytokines, viruses, G-protein-coupled receptor ligands and oncogenes activate the ERK pathway. Key molecules in the ERK/MAPK signalling pathway mainly include the small G proteins Ras and downstream Raf kinase, MEK1/2 and ERK1/2.

Recent studies have substantially expanded our knowledge of the MAPK-ERK pathway signaling, allowing the development of diverse potential therapeutic strategies targeting the pathway. This Special Issue covers recent advances in the molecular mechanisms and functions of MAPK-ERK signaling in different biological contexts.

The Ras/Raf/MAPK (MEK)/ERK pathway is the most important signalling cascade among all MAPK signal transduction pathways, and plays a crucial role in the survival and development of tumour cells. The present review discusses recent studies on Ras and ERK pathway members.

Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5.

GEF 蛋白将信号传递到小 GTP 结合蛋白 (Ras、Rap1)。 GTP 结合蛋白激活级联的核心单位，级联单位包括一个 MAPKKK (Raf)、一个 MAPKK (MEK1/2) 和 MAPK (Erk)。激活的 Erk 可在胞质中调控靶标，也可转位到胞核磷酸化各种调控基因表达的转录因子。