In enzymology, a formaldehyde dehydrogenase (EC 1.2.1.46) is an enzyme that catalyzes the chemical reaction. The 3 substrates of this enzyme are formaldehyde, NAD +, and H 2 O, whereas its 3 products are formate, NADH, and H +.

2022年2月22日 · The enzyme formaldehyde dehydrogenase (FalDH) from Pseudomonas putida is of particular interest for biotechnological applications as it catalyzes the oxidation of formaldehyde independent of glutathione.

The enzymes involved in the dissimilation of formaldehyde can be categorized into three classes based on their co-factor dependence: 1) formaldehyde dehydrogenases (Flds) that directly oxidize formaldehyde, such as that from Pseudomonas aeruginosa (Tsuru et al., 1997); 2) Flds that depend on a thiol (glutathione or mycothiol), such as those from...

Formaldehyde dehydrogenase (FDH) is a member of the zinc-containing medium-chain alcohol dehydrogenase family which oxidizes toxic formaldehyde to formate using NAD (+) as an electron carrier. Three-dimensional structures have been reported for FDHs from several different species.

Nearly all organisms have an enzyme, formaldehyde dehydrogenase, which decomposes this chemical. The trick is to feed it into the system slowly enough so that it is diluted below toxic concentrations by the normal flow of water.

Formaldehyde is a product of JmjC-dependent histone demethylation, and this assay couples formaldehyde formation with the formation of NADH by a formaldehyde dehydrogenase (FDH). FDH oxidizes formaldehyde to formic acid with concomitant reduction of NAD + to NADH.

As a member of zinc-containing medium-chain alcohol dehydrogenase family, formaldehyde dehydrogenase (FDH) can oxidize toxic formaldehyde to less active formate with NAD(+) as a cofactor and exists in both prokaryotes and eukaryotes.

The P. putida formaldehyde dehydrogenase (P-FDH) [EC 1.2.1.46] (Ogushi, et al., 1984a) meets the operational criteria of an aldehyde dehydrogenase. When P-FDH is incubated with NAD+ and either formaldehyde or acetaldehyde it catalyzes the production of NADH as...

2013年9月1日 · Formaldehyde dehydrogenase (FDH) is a member of the zinc-containing medium-chain alcohol dehydrogenase family which oxidizes toxic formaldehyde to formate using NAD + as an electron carrier. Three-dimensional structures have been reported for FDHs from several different species.

2024年10月29日 · There is a variety of formaldehyde dissimilation pathways across microorganisms, often based on the activity of formaldehyde dehydrogenases. In this study, we investigated the role of the yycR gene of Bacillus subtilis putatively encoding a novel, uncharacterized zinc-type alcohol dehydrogenase-like protein.