Holoprosencephaly (HPE) is a birth defect (congenital condition) that causes the fetal brain to not properly separate into the right and left hemispheres (halves). HPE ranges in severity and also often causes facial development issues.

Holoprosencephaly (HPE) is a cephalic disorder in which the prosencephalon (the forebrain of the embryo) fails to develop into two hemispheres, typically occurring between the 18th and 28th day of gestation. [1]

What is Holoprosencephaly? Holoprosencephaly (HPE) is a condition that changes the way a baby’s brain develops. In HPE, the left and right sides of the brain do not separate like they should. The severity of HPE depends on how much of the brain separated properly.

2024年6月7日 · Holoprosencephaly (HPE) results from an incomplete midline cleavage of the forebrain (prosencephalon). It includes a wide spectrum of intracranial and craniofacial midline defects and a myriad of clinical manifestations, consisting of neurologic impairment and dysmorphism of the brain and face.

2018年5月9日 · Holoprosencephaly is a malformation sequence with a very variable degree of severity for both the brain and facial abnormalities. Intellectual disability is associated with HPE and seizures are often present.

Holoprosencephaly is an abnormality of brain development in which the brain doesn't properly divide into the right and left hemispheres. The condition can also affect development of the head and face. There are 4 types of Holoprosencephaly, distinguished by severity.

2024年3月13日 · Holoprosencephaly (HPE) is a rare congenital anomaly in which an embryo’s brain does not properly divide into two halves, known as the left and right hemispheres. HPE affects brain...

2012年1月3日 · Holoprosencephaly is a disorder caused by the failure of the prosencephalon (the embryonic forebrain) to sufficiently divide into the double lobes of the cerebral hemispheres. The result is a single-lobed brain structure and severe skull and facial defects.

2000年12月27日 · Holoprosencephaly (HPE), the most common malformation of the forebrain in humans, is a structural anomaly of the brain resulting from failed or incomplete forebrain division in the third to fourth weeks of gestation; the forebrain (prosencephalon) incompletely cleaves into right and left hemispheres, deep brain structures, and the olfactory and ...

2024年8月28日 · Holoprosencephaly (HPE) is a rare congenital brain malformation resulting from incomplete separation of the two hemispheres. Classically three subtypes have been recognized, however additional entities are now included in the spectrum of the disease.