Apr 15, 2024 · All of the employed polymers have gel-forming ability. Hypromellose was selected due to its bioadhesive properties and good film-forming abilities [36,37,38,39]. The type applied in this study, 90SH, with an average viscosity of 4000 mPa·s, allows for the preparation of swelling polymer matrices used as carriers for prolonged-release drugs ...

Sep 1, 2022 · Gels are matrices of a gelling agent and a liquid component, forming a three-dimensional network structure characterized by stiffness and elasticity properties. Depending on their composition and preparation method, gels can be classified as hydrogels, organogels, emulgels, bigels, aerogels, xerogels, or cryogels.

Aug 10, 2020 · The process of hydration of the polymeric structure of HPMC is thermally dependent and significantly influences the formation and the structure of resultant gel. Aqueous HPMC solutions exhibit inverse thermally-induced reversible behavior (sol-gel transitions at rather high temperatures), which is often accompanied by clouding of the solution.

HPMC, for example, has the ability to swell and form a gel layer, which allows control of the drug release rate on the surface of matrix systems, and therefore, it is used in the development of...

Hypromellose in an aqueous solution, like methylcellulose, exhibits a thermal gelation property. That is, when the solution heats up to a critical temperature, the solution congeals into a non-flowable but semi-flexible mass.

Sep 1, 2022 · This bi-phasic gel had gellan and κ-carrageenan as the constitutive elements in the aqueous and the organic phase, respectively. Physicochemical studies revealed the influence of organogel in eliciting high mechanical strength and smooth surface morphology to the bigel.

Sol-gel transformations in HPMC (hydroxypropyl methylcellulose) are being increasingly studied because of their role in bio-related applications. The thermo-reversible behavior of HPMC is particularly affected by its properties and concentration in solvent media, nature of additives, and the thermal environment it is exposed to.

Jan 1, 2014 · Hydrophilic matrix tablets (matrices) for oral use are designed to hydrate on swallowing, and form a ‘gel’ layer of hydrated polymer at the tablet surface to control the rate of drug release during passage of the matrix through the gastrointestinal tract.

Oct 8, 2014 · The mechanism of the formation of HPS gel is the twine of the double helix of amylose through hydrogen bond during the cooling process. While HPMC is a thermal gel that forms hydrogel at higher temperature and its gel disaggregates at lower temperature, which is different from the common hydrogels, such as gelatin and modified starches [11, 12].

Aug 1, 2022 · The novel sugar amine-derived gel, that is poly(vinyl benzyl-N-methyl-D-glucamine) gel (poly(VbNMDG) gel), was obtained by the subsequent polymerization of the neutral form (VbNMDG) and...