2024年1月1日 · The findings suggested that the ibuprofen conjugate might possess the potential to manage the complications of AD. The action appears to be mediated through inhibition of beta-secretase and acetylcholinesterase activities. More studies might aid in identifying a specific therapeutic intervention that is still lacking in the treatment of AD.

2006年1月1日 · Here we show that the effect of ibuprofen and other NSAIDs on BACE1 expression and Aβ secretion is specifically mediated by PPARγ. Importantly, BACE1 transcription was found to be up-regulated in MEF PPARγ knockout cells compared with wild-type cells.

2003年10月29日 · The inhibitory action of ibuprofen and indomethacin was suppressed by PPARgamma antagonists. Finally, we observed that the mRNA levels, expression, and enzymatic activity of beta-secretase were increased by immunostimulation and normalized by NSAIDs.

2015年8月5日 · Ibuprofen is one of the nonsteroidal anti-inflammatory drugs that have been shown to selectively lower pathogenic amyloid beta-peptide (Aβ)42 without impairing overall γ-secretase activity in vitro.

2005年1月26日 · We present evidence supporting the hypothesis that ibuprofen-dependent amyloid reduction is mediated by inhibition of an alternate pathway (IL-1 β and its downstream target ACT).

2006年1月10日 · Here we show that PPARgamma depletion potentiates beta-secretase [beta-site amyloid precursor protein cleaving enzyme (BACE1)] mRNA levels by increasing BACE1 gene promoter activity. Conversely, overexpression of PPARgamma, as well as NSAIDs and PPARgamma activators, reduced BACE1 gene promoter activity.

2003年10月29日 · Ibuprofen and pioglitazone decreased the generation of both Aβ 1–40 and Aβ 1–42 levels ( Fig. 4 D ). To determine whether NSAIDs other than ibuprofen could reduce Aβ generation, we examined the role of indomethacin, which acts as a nonselective COX inhibitor as well as a PPARγ agonist ( Lehmann et al., 1997 ).

2001年12月1日 · Ibuprofen treatment decreased the secretion of total Aβ in the conditioned media of cytokine stimulated cells by 50% and prevented the accumulation of Aβ-42 and Aβ-40 in detergent soluble cell extracts.

The findings suggested that the ibuprofen conjugate might possess the potential to manage the complications of AD. The action appears to be mediated through inhibition of beta-secretase and acetylcholinesterase activities. More studies might aid in identifying a specific therapeutic intervention tha …

2003年8月15日 · We now show in cell-based assays that intramembrane cleavage of APP and ErbB-4 receptor is not impaired by the Aβ42-lowering NSAIDs, sulindac sulfide and ibuprofen. Generation of the APP intracellular domain (AICD) was further not inhibited in a cell-free assay at concentrations far exceeding those effective in reducing Aβ42 production.