2014年8月8日 · Inosine (hypoxanthine 9-beta-D-ribofuranoside), a purine nucleoside with multiple intracellular roles, also serves as an extracellular modulatory signal. On neurons, it can …

2021年8月23日 · The therapeutic effects of inosine, which regulates neuron activity, have been described in literature by several research groups. In the last four decades, studies have …

2002年6月25日 · The purine nucleoside inosine enters cells via facilitated diffusion or can be synthesized readily from adenosine. In at least some neurons, inosine activates an …

2023年11月1日 · Inosine is a purine nucleoside that increases brain-derived neurotrophic factor (BDNF) expression in the brain through adenosine receptors. Herein, we investigated the …

2009年6月6日 · Inosine, a naturally occurring purine nucleoside, stimulates neurons to extend axons in culture and, in vivo, enhances the ability of undamaged neurons to form axon …

2022年7月21日 · Here, we review the current preclinical and clinical studies investigating the use of inosine in AD, PD, ALS, and MS. The most important properties of inosine seem to be its …

Inosine (molecular formula: C 10 H 12 N 4 O 5) can exert neuroprotective effects that might be due to its anti-inflammatory and antioxidant properties. Interestingly, it has been suggested …

Inosine, an inert purine nucleoside, is formed by breakdown (deamination) of adenosine both intracellularly and extracellularly; it also generated by the action of 5′-nucleotidase on inosine …

Following ischemia, dying, injured, and hypoxic cells release soluble purine-nucleotide and -nucleoside pools. Growing evidence suggests that purine nucleosides might act as trophic …

In vivo, inosine stimulates extensive axon growth in the mature rat corticospinal tract. Following unilateral transection of the corticospinal tract, inosine applied to the intact sensorimotor cortex …