Oct 13, 2021 · We report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH 3, R = H, Me), at room temperature without using...

Aug 17, 2023 · Based on control experiments, material characterizations, and DFT computations, we suggest metallic nickel and low-valent Ti-species to be crucial factors that makes this direct amide synthesis...

The use of [4- (acetylamino)phenyl]imidodisulfuryl difluoride (AISF) as a carboxylic acid activator enables an efficient synthesis of amides and peptides containing amino acids as well as aryl acids and amines under mild conditions.

In this work, we report the result that NaAB directly reacts with esters to quantitatively form the corresponding primary amides within 5 min at room temperature, without any catalyst and...

Nov 8, 2016 · This synopsis surveys the diverse recent approaches to amide synthesis from nonactivated carboxylic acids and derivatives as well as noncarboxylic compounds, highlighting the most innovative methodologies and those that are more eco-friendly compared to traditional methods while focusing on recent developments during the past two years.

Dec 18, 2024 · Here, we present an efficient and rapid method for the synthesis of primary amides by a one-pot reaction of NH 3 gas and unactivated esters at ambient temperature, in which sodium hexamethyldisilazide was used to initiate the reaction by abstracting a …

We report here a facile synthesis method of primary and secondary amides through a direct amidation of esters with sodium amidoboranes (NaNHRBH 3, R = H, Me), at room temperature without using catalysts and other reagents.

Jan 1, 2022 · We have developed a mild method using simple esters and amines with a Grignard reagent to synthesise, amides, carbamates and ureas (symmetrical and unsymmetrical). The method is significant in its simplicity, wide scope and the molecules that can be accessed.

Dec 8, 2024 · This review provides a comprehensive overview of recent advancements in amide synthesis, with a specific focus on methods utilizing organocatalysis and organoboron-based catalysis for the direct cond...

Amide formation is a ubiquitous reaction in organic chemistry, but suffers from the problem of generating large amounts of waste. Here, the authors report a catalytic amide synthesis by the ruthenium catalysed addition of carboxylic acids to acetylenes, followed by reaction with primary or secondary amines.