2009年2月1日 · Once macrocytosis is identified, the history and physical examination help narrow the differential diagnosis. The presence of anemia, the degree of elevation of the mean corpuscular volume,...

2022年7月11日 · Macrocytic anemia refers to macrocytosis (mean corpuscular volume (MCV) greater than 100 fL) in the setting of anemia (hemoglobin less than 12 g/dL or hematocrit (Hct) less than 36% in nonpregnant females, hemoglobin less than 11 g/dL in pregnant females, or hemoglobin less than 13 g/dL or Hct less than 41% in males).

10. Differential Diagnosis of Macrocytic Anemias. Once macrocytosis has been identified, differential diagnosis should begin with determining the serum levels of vitamin B12 and folate and examining the peripheral blood smear (Figure 1). Macrocytic cells are red blood cells larger than the nucleus of a small lymphocyte.

Macrocytic anemia: MCV is above the normal range (> 100 fL), signifying larger than normal red blood cells. This is a key indicator for further investigation into possible megaloblastic anemia (vitamin B12 or folate deficiency) or other causes.

examination help narrow the differential diagnosis. The presence of anemia, the degree of elevation of the mean corpuscular volume, and the patient’s overall health

Macrocytosis is defined as a mean corpuscular volume greater than 100 femtolitres (fL). There are several causes for macrocytic anaemia, and they can be divided into megaloblastic or non-megaloblastic anaemia. Vitamin B12 deficiency is one of the most common causes of megaloblastic anaemia.

Macrocytic anemia can usually be divided into two categories, megaloblastic and nonmegaloblastic, based on the examination of the bone marrow. This categorization is important and frequently aids in determining the etiology of the anemia.

The most common causes of macrocytic anemias in the adults are (1) alcoholism, (2) liver diseases, (3) hemolysis or bleeding, (4) hypothyroidism, (5) folate or vitamin B12 deficiency, (6) exposure to chemotherapy and other drugs, and (7) myelodysplasia.

1992年5月1日 · Most adult patients who are not receiving antineoplastic agents and who have a significant oval macrocytic anemia and normal serum vitamin B12 and folate levels will have myelodysplasia. This diagnosis can be firmly established by evaluating a marrow aspirate and biopsy specimen in most patients.

This topic discusses causes of macrocytosis and macrocytic anemia. Additional topics discuss the following: Microcytosis/microcytic anemia – (See "Microcytosis/Microcytic anemia".) General anemia evaluation. • Child – (See "Approach to the child with anemia".) • Adult – (See "Diagnostic approach to anemia in adults".)