2016年10月11日 · Myelin is essential to the conduction of nerve impulses in the brain and spinal cord, and myelin loss is a key pathophysiological component of neurological injury and disease, including multiple sclerosis, traumatic brain and spinal cord injury, stroke, and some neuropsychiatric disorders.

2024年4月27日 · In this disease, the immune system attacks the myelin sheath or the cells that produce and maintain it. The attack causes swelling, also known as inflammation, and injury to the myelin sheath. Ultimately, the nerve fibers the myelin sheath surrounds are damaged. The process can result in areas of scarring, known as sclerosis. Other causes

2024年1月3日 · Myelin oligodendrocyte glycoprotein antibody-associated disease, also known as MOGAD, is a rare inflammatory disease that affects the central nervous system. In MOGAD , the immune system attacks the fatty substance that protects nerve fibers in the optic nerves, brain and spinal cord.

2024年1月3日 · Sechi E, et al. Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): A review of clinical and MRI features, diagnosis, and management. The Frontiers in Neurology. 2022; doi:10.3389/fneur. 2022.885218 .

In multiple sclerosis, the protective coating on nerve fibers, known as myelin, in the central nervous system is damaged. Depending on the location of the damage in the central nervous system, symptoms may happen, including numbness, tingling, weakness, visual changes, bladder and bowel troubles, memory troubles, or mood changes, for example.

2024年11月22日 · The MOGAD Clinic helps people with a rare, newly defined condition called myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD). It's an autoimmune disorder in which the body's immune system attacks the outer covering of its nerves, called myelin. This leads to inflammation of the brain, optic nerve or spinal cord.

2024年1月3日 · Called MOGAD, which stands for myelin oligodendrocyte glycoprotein associated-antibody disease, the rare, immune-mediated illness has been present in Joe’s life since February 2016, when, at the age of 55,…

2024年11月1日 · In multiple sclerosis, the protective coating on nerve fibers, known as myelin, in the central nervous system is damaged. Depending on the location of the damage in the central nervous system, symptoms may happen, including numbness, tingling, weakness, visual changes, bladder and bowel troubles, memory troubles, or mood changes, for example.

Guillain-Barre syndrome destroys the protective covering of the peripheral nerves (myelin sheath), preventing the nerves from transmitting signals to the brain. There is a problem with information submitted for this request.

2018年4月3日 · During adulthood, PAR2-/-mice exhibited higher levels of myelin basic protein and thickened myelin sheaths," explains Isobel A. Scarisbrick, Ph.D., director of the Neuroregeneration and Neurorehabilitation Laboratory at Mayo Clinic's campus in Minnesota and the study's principal investigator. "Genetic targeting of PAR2 fostered myelin ...