Oxidative stress plays an important role in the development of nitrate tolerance and endothelial dysfunction in response to organic nitrates, although the extent and the cellular source of oxidative stress differ markedly between the ISMN, ISDN, and GTN.

2011年2月15日 · Mechanistically, dietary nitrate restored the tissue levels of bioactive nitrogen oxides and reduced the levels of oxidative stress markers in plasma (malondialdehyde) and urine (Class VI F2-isoprostanes and 8-hydroxy-2-deoxyguanosine).

An increase in the content of reactive nitrogen species may result in nitrosative stress—a deleterious process, which can be an important mediator of damage to cell structures, including lipids, membranes, proteins and DNA.

Nitric oxide and reactive oxygen species, but not peroxynitrite, are overproduced in patients with cirrhosis in spite of evidence of an increase in antioxidant defenses. This suggests that therapeutic measures aimed at attenuating oxidative stress as well as increasing antioxidant defenses may well …

Oxidative stress, that is, the imbalance between production of reactive oxygen species (ROS) and/or reactive nitrogen species (RNS) on the one side and antioxidative defense on the other side, is related with numerous diseases, along with some specific conditions such as hyperoxia, ageing, and physical exercise . The direct damaging result of ...

2004年2月1日 · Recent data have suggested that the denitrification of organic nitrates is mediated by mitochondrial aldehyde dehydrogenase and that dysfunction of this enzyme is an important cause of tolerance. In this issue of the JCI, evidence in support of this hypothesis is presented in an in vivo model of nitrate tolerance.

Oxidative stress has been identified as an important factor in the development of tolerance to organic nitrates. This review examines the evidence supporting this recently developed theory and how mechanisms of nitrate tolerance may link with the wider picture of …

2010年11月19日 · Mechanistically, dietary nitrate restored the tissue levels of bioactive nitrogen oxides and reduced or normalized the levels of oxidative stress markers and dimethylarginines. Future studies will reveal if nitrate contributes to the well-known cardioprotective effects of a diet rich in vegetables.

vasoprotective effects were attributable to the activity of nitrite converted from the ingested nitrate. These findings suggest that dietary nitrate underlies the beneficial effects of a vegetable-rich diet and highlights the potential of a “natural” low cost approach for the treatment of cardiovascular disease. (Hypertension. 2008;51:784-790.)

2012年4月6日 · Various studies on nitrates and nitrites including their widespread applications, mechanisms of action and biological effects due to their ability to induce oxidative stress have been reviewed.