- The canonical nucleosome, which represents the major packaging unit of eukaryotic chromatin, has an octameric core composed of two histone H2A-H2B and H3-H4 dimers with ∼147 base pairs (bp) of DNA ...pubmed.ncbi.nlm.nih.gov/36322721/
In vivo assembly of complete eukaryotic nucleosomes and (H3-H4) …
2024年11月14日 · Development of an in vivo system for assembly of eukaryotic nucleosomes in Escherichia coli, including the non-canonical (H3-H4)4 octasome, suggests the H3-H4 tetrasome and octasomes are...
Nucleosome - Wikipedia
Pioneering structural studies in the 1980s by Aaron Klug's group provided the first evidence that an octamer of histone proteins wraps DNA around itself in about 1.7 turns of a left-handed superhelix. In 1997 the first near atomic resolution crystal structure of the nucleosome was solved by the Richmond group, showing the most important details of the particle. The human alpha satellite
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- Nucleosome H3 H4 的研究
DNA polymerase δ subunit Pol32 binds …
2024年8月9日 · Our research revealed that Pol32 binds histone H3-H4 and contributes to nucleosome assembly on lagging strands, providing a novel mechanism for replisome …
A replisome-associated histone H3-H4 chaperone required
2024年8月1日 · A histone H3-H4 binding domain in the Mrc1/CLASPIN component of the replisome is required for parental histone transfer and epigenetic inheritance of …
DNA polymerase α interacts with H3-H4 …
Immediately following replication, replicated DNA is assembled into nucleosomes by two pathways, de novo deposition of newly synthesized H3-H4 and the transfer of parental histone H3-H4 …
RPA binds histone H3-H4 and functions in …
2017年1月27日 · In vitro binding assays demonstrated that recombinant RPA directly binds free H3-H4, but not (mono)nucleosomal histone H3-H4 and free histone H2A-H2B …
Histone H3 and H4 tails play an important role in nucleosome …
Taking a reductionist approach to investigate H3 and H4 tail peptide interactions in-trans with DNA and nucleosome core particles supports the direct involvement of these tails in chromatin …
Structural insights into instability of the nucleosome driven by ...
2024年10月1日 · The nucleosome, composed of histone octamer containing histones H2A-H2B dimer and H3–H4 tetramer, wrapped by the 147 base pairs of DNA, is the fundamental …
Cryo–electron microscopy structure of the H3-H4 octasome: A …
2022年11月11日 · Using cryo–electron microscopy, we solved the structure of the H3-H4 octasome, a nucleosome-like particle with a di-tetrameric core consisting exclusively of the H3 …
FACT- (H3-H4) complex stimulates Pol α activity to ... - bioRxiv
2024年8月8日 · Deficiencies in replication-coupled (RC) nucleosome assembly often lead to reduced DNA replication rate, but the precise mechanism underlying this process remains …
Nucleosome H3 H4 的相关搜索
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