Nucleic acid metabolism is a collective term that refers to the variety of chemical reactions by which nucleic acids (DNA and/or RNA) are either synthesized or degraded. Nucleic acids are polymers (so-called "biopolymers") made up of a variety of monomers called nucleotides.

2025年1月16日 · The Nucleotide Metabolism page details the synthesis and degradation of the nucleic acids as well as descriptions of diseases caused by defects in their metabolism.

Overview of nucleotide metabolism. Nucleotides are key components of DNA and RNA (genetics), provide energy (ATP), and can activate signaling pathways. QUICK GUIDE TO NUCLEOTIDES

Nucleotide metabolism is a critical pathway that generates purine and pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics. Increased nucleotide metabolism supports uncontrolled growth of tumors and is a hallmark of cancer.

Nucleotide metabolism is a common metabolic vulnerability of proliferating tumors. Metastasis formation depends on energy and antioxidant metabolism. Cancer cells impair the anti-tumor immune response.

2023年8月31日 · Synthesis of ribonucleotides by the de novo method occurs in two pathways – one for purines and one for pyrimidines. What is notable about both of these pathways is that nucleotides are built …

2023年8月4日 · essential for all cells. Without them, neither ribonucleic acid (RNA) nor deoxyribonucleic acid (DNA) can be produced, and, therefore, proteins cannot be synthesized .

2023年3月27日 · Metabolic alterations are a key hallmark of cancer cells, and the augmented synthesis and use of nucleotide triphosphates is a critical and universal metabolic dependency of cancer cells across...

Nucleotide synthesis is an energy intensive process that uses multiple metabolic pathways across different cell compartments and several sources of carbon and nitrogen. The processes are regulated at the transcription level by a set of master transcription factors but also at the enzyme level by allosteric regulation and feedback inhibition.

2010年1月8日 · Nucleotide metabolism is necessary to maintain substrates that support the formation of the high-energy intermediate ATP and guanosine triphosphate (GTP). In the RBC, adenine and phosphoribosylpyrophosphate are converted to AMP, and adenosine can be activated to AMP by ATP.