p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in …

1995年7月11日 · Mutations in the p53 tumor suppressor are the most frequently observed genetic alterations in human cancer. The majority of the mutations occur in the core domain which …

The gene encoding the p53 tumor suppressor protein, a sequence-specific DNA binding transcription factor, is the most frequently mutated gene in human cancer. Crystal structures of …

p53 tumor suppressor is a flexible molecule composed of four identical protein chains. Flexible molecules are difficult to study by x-ray crystallography because they do not form orderly …

1999年9月15日 · Like many transcription factors, p53-like proteins are modular molecules with a conserved transcriptional activation domain, DNA-binding domain and an oligomerization …

2023年3月1日 · For the first time, a Penn State-led team of researchers uncovered the complete structure of the p53 protein using patient samples. They also investigated how mutation …

P53 Protein Domain Structure A. The 393-amino acid residue p53 protein comprises an amino-terminus transactivation domain (blue), followed by a proline-rich region (purple), a central …

1996年10月16日 · The p53 tumor suppressor protein is involved in multiple central cellular processes, including transcription, DNA repair, genomic stability, senescence, cell cycle …

The tumor suppressor protein p53, known as "the guardian of the genome," protects the body's DNA from daily stress or long-term damage by triggering the cells to make repairs or to...

As described in this chapter, significant progress has been made towards understanding its three-dimensional structure. The structural information has helped our understanding of p53 function …