Palpable purpura is the clinical manifestation of leukocytoclastic vasculitis, which can be idiopathic or linked to sepsis, reactions to drugs, connective tissue diseases, cryoglobulinemia, hepatitis C or B infection, or underlying cancers.

What is purpura? Purpura is the name given to the discolouration of the skin or mucous membranes due to haemorrhage from small blood vessels. Petechiae are small, purpuric lesions up to 2mm across; Ecchymoses or bruises are larger extravasations of blood. Palpable purpura is purpura than can be felt, due to inflammation of the blood vessels

Unlike petechiae and ecchymoses, palpable purpura is a condition in which raised, purpuric papules and plaques can range from a few millimeters to a few centimeters in diameter. Palpable purpura favors dependent areas such as the lower extremities, but in the supine patient, lesions can occur on the back, buttocks, and distal arms.

This picture shows immunofluorescence testing of a skin biopsy, IgA positive. Palpable purpura should be biopsied, and two fresh samples should always be sent for testing (an adequate biopsy should be large enough to divide; one for H&E (hematoxylin …

2020年8月15日 · Henoch-Schönlein purpura, now called immunoglobulin A (IgA) vasculitis, is a systemic, immune complex–mediated, small-vessel leukocytoclastic vasculitis characterized by...

2020年5月1日 · Petechiae and purpura are common when the platelet count is severely low, whereas systemic symptoms, such as arthralgias or abdominal discomfort, are not present.

Cutaneous small vessel vasculitis is localized to the skin, usually on the lower legs, and presents with palpable purpura.

2016年1月23日 · Small vessel vasculitis is the most common form of vasculitis affecting arterioles and venules. In the skin, small vessel vasculitis presents with palpable purpura. Cutaneous small-vessel vasculitis can be idiopathic / primary, or secondary to infection, drug or disease. It may be neutrophilic, lymphocytic or granulomatous on histopathology.

Cutaneous vasculitis, secondary to drug reaction, infection or collagen vascular disease, is the most common identifiable cause of palpable purpura. Common causes of palpable purpura often can be identified during the patient's history and physical examination.

2023年9月26日 · Identify the clinical manifestations and typical presentation of IgA vasculitis, including palpable purpura, gastrointestinal complaints, arthralgias, and renal involvement. Differentiate IgA vasculitis from other vasculitic conditions with similar clinical features, especially IgA nephropathy, ensuring accurate diagnosis and appropriate treatment.