2024年8月1日 · In this study, we aimed to explore the shared pathogenic mechanisms underlying psoriasis and atopic dermatitis (AD). We analyzed and identified SGK1 hi macrophages and TIGIT hi T cells present in both diseases, demonstrating that inhibiting SGK1 could exacerbate both psoriasis and AD.

Atopic dermatitis (AD) and psoriasis are chronic inflammatory skin diseases associated with a significant cutaneous and systemic burden of disease as well as a poor health-related quality of life. Here, we review the complex pathophysiology of both AD and psoriasis and discuss the implications for treatment with current state-of-the-art and ...

We review similarities between the diseases and differences in epidermal barrier defects and immune cells. We also propose mechanisms of pathogenesis based on differences in the balance of immune cell subsets that could cause the phenotypes that distinguish these diseases.

We review similarities between the diseases and differences in epidermal barrier defects and immune cells. We also propose mechanisms of pathogenesis based on differences in the balance of immune cell subsets that could cause the phenotypes that distinguish these diseases.

2017年10月1日 · This review is focused on describing pathogenic disease mechanisms across the spectrum of both diseases and associated sub-types with a perspective that many immunological mechanisms overlap between psoriasis and AD and thus some treatment approaches may be common across the disease spectrum [8].

We review similarities between the diseases and differences in epidermal barrier defects and immune cells. We also propose mechanisms of pathogenesis based on differences in the balance of immune cell subsets that could cause the phenotypes that distinguish these diseases.

This study aims to explore the common pathogenic mechanisms of psoriasis and atopic dermatitis, two T-cell-mediated auto-immune diseases. Utilizing single-cell transcriptomic sequencing data, we revealed that Treg cells primarily express TIGIT in both psoriasis and atopic dermatitis, and identied a subset of macrophages that highly express SGK1.

2011年6月1日 · Atopic dermatitis (AD) and psoriasis are characterized by infiltration of skin lesions by large numbers of T cells, dendritic cells (DCs), and other inflammatory cells (see Fig 3 in part 1 of the review 1). 2, 3, 4, 5, 6, 7 We discuss the immune cells and factors that mediate the inflammation associated with AD (Fig 1).

Immune mechanisms of atopic dermatitis and psoriasis. (A) Atopic dermatitis lesions are characterized by dendritic cells and Langerhans cells activated by the release of IL-25, IL-33 and TSLP from keratinocytes.

2024年8月1日 · This study aims to explore the common pathogenic mechanisms of psoriasis and atopic dermatitis, two T-cell-mediated autoimmune diseases. Utilizing single-cell transcriptomic sequencing data, we revealed that Treg cells primarily express TIGIT in both psoriasis and atopic dermatitis, and identified a …