A drug allergy should always be suspected in a patient presenting with a whole-body rash and eosinophilia, especially if a new medication was recently started. Allopurinol-induced DRESS syndrome is associated with significant mortality (10%).

Apr 3, 2024 · If you develop a rash (even a mild one) while taking allopurinol, stop taking it and contact your prescriber immediately. If you experience severe allopurinol side effects, like swelling in the face or lips or difficulty breathing, call 911 or seek emergency care.

Skin rashes. Stevens-Johnson syndrome is a rare side effect of allopurinol. It causes flu-like symptoms, followed by a red or purple rash that spreads and forms blisters. The affected skin eventually dies and peels off. It's more likely to happen in the first 8 weeks of taking allopurinol, or when the dose is increased too quickly.

Jun 3, 2024 · Skin rash is one of the most common adverse reactions and may occur at any time during treatment. Some skin reactions can be severe and sometimes fatal. In patients with the most severe reactions, systemic symptoms such as fever, chills, arthralgia, cholestatic jaundice, eosinophilia and mild leukocytosis, or leukopenia accompany the rash.

During the treatment with allopurinol, patients may commonly experience rash, gout flares, gastrointestinal symptoms, elevation in hepatic enzymes, hematologic abnormalities and drowsiness .

Jun 13, 2012 · If you develop a skin rash while taking allopurinol, you should stop taking the medication immediately. You should then go and see your physician. If the rash is mild, you can use a gentle medicated skin cream such as E45 cream to soothe the skin and relieve the itching and other symptoms.

Oct 16, 2012 · Allopurinol rash can be dangerous, but so can untreated gout. How can you stop gout, save your crumbling joints, & still avoid side-effects? See how to be safe.

Apr 25, 2023 · Typically, a skin rash caused by allopurinol appears as flat, raised bumps on your skin. You may also notice a scale-like appearance to the rash. The bumps may also blister or peel.

Dec 12, 2022 · If you notice a skin rash while taking allopurinol, immediately stop taking the drug and contact your doctor. Even a mild skin rash can turn into severe symptoms of an allergic reaction to ...

Jan 22, 2025 · Skin Rash and Hypersensitivity: Allopurinol has been associated with serious and sometimes fatal dermatological reactions. Discontinue allopurinol tablets at the first appearance of skin rash or other signs of hypersensitivity reaction. …